GYG1 Antibody

1. we screened the susceptibility loci for Myocardial infarction (MI) using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. PMID: 29321365
2. We present functional evidence for the pathogenicity of a novel GYG1 missense mutation located in the substrate binding domain. PMID: 29143313
3. This study found a single homozygous intronic mutation of GYG1 harbored by five patients, who, except for two siblings, appear to be unrelated but all five live in central or south Sardinian villages. PMID: 26652229
4. Depletion of glycogenin-1 and impaired interaction with glycogen synthase underlies a new form of glycogen storage disease. PMID: 25272951
5. The glucosylation of glycogenin-2 was enhanced to 2-4 glucose units by the co-presence of enzymatically active glycogenin-1. PMID: 24239874
6. results explain the glycogen depletion in the patient expressing only Thr83Met glycogenin-1 and why heterozygous carriers without clinical symptoms show a small proportion of unglucosylated glycogenin-1 PMID: 22198226
7. Results show that glycogenin becomes inactivated with glycogen catabolism and that this event coincides with an increase in glycogenin gene expression as exercise and glycogenolysis progress. PMID: 15860684
8. during recovery from prolonged exhaustive exercise, glycogenin mRNA and protein content and activity increase in muscle PMID: 15870102
9. GN-1 is conserved, possibly as very small, or nascent, granules when glycogen concentration is low. This would provide the ability to rapidly restore glycogen during early recovery. PMID: 17311895

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HGNC: 4699

OMIM: 603942

KEGG: hsa:2992

STRING: 9606.ENSP00000340736

UniGene: Hs.477892