GZMM Antibody, Biotin conjugated

Code CSB-PA010085LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GZMM Polyclonal antibody
Uniprot No.
Target Names
GZMM
Alternative Names
GRAM_HUMAN antibody; Granzyme M (lymphocyte met ase 1) antibody; Granzyme M antibody; GranzymeM antibody; GZM M antibody; Gzmm antibody; HU Met 1 antibody; HU-Met-1 antibody; LMET 1 antibody; LMET1 antibody; Lymphocyte met ase 1 antibody; MET 1 antibody; Met 1 serine protease antibody; Met ase antibody; Met-1 serine protease antibody; Met-ase antibody; MET1 antibody; Met1 serine protease antibody; Natural killer cell granular protease antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Granzyme M protein (98-243AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
Gene References into Functions
  1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced. PMID: 27441655
  2. We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain. PMID: 27133719
  3. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients. PMID: 24316590
  4. GrM is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K in the presence of RNA. PMID: 23099853
  5. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. PMID: 21979465
  6. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death. PMID: 21857942
  7. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes. PMID: 20107908
  8. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. PMID: 21059895
  9. survivin cleavage by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells PMID: 20406824
  10. These findings support not only a role for GrM in the innate but also in the adaptive immune response. PMID: 19896187
  11. GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity. PMID: 12506019
  12. granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells PMID: 15028722
  13. Granzyme (Gzm)M can directly degrade inhibitor of caspase-activated DNase (ICAD) to activate CAD, leading to DNA damage; GzmM cleaves DNA damage sensor enzyme poly(ADP-ribose) polymerase to prevent cellular DNA repair and force apoptosis. PMID: 16818775
  14. Granzyme M targets major components of the cytoskeleton that likely contribute to natural killer (NK) cell-induced cell death. PMID: 18523284
  15. NPM is essential for cell viability, these data suggest that targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function. PMID: 19103589
  16. Structure-based mutagenesis reveals that the amino-terminus and catalytic triad of GzmM are most essential for proteolytic function. PMID: 19542453

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Subcellular Location
Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.
Protein Families
Peptidase S1 family, Granzyme subfamily
Tissue Specificity
Highly and constitutively expressed in activated natural killer (NK) cells.
Database Links

HGNC: 4712

OMIM: 600311

KEGG: hsa:3004

STRING: 9606.ENSP00000264553

UniGene: Hs.465511

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