GZMM Antibody

1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced. PMID: 27441655
2. We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain. PMID: 27133719
3. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients. PMID: 24316590
4. GrM is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K in the presence of RNA. PMID: 23099853
5. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. PMID: 21979465
6. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death. PMID: 21857942
7. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes. PMID: 20107908
8. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. PMID: 21059895
9. survivin cleavage by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells PMID: 20406824
10. These findings support not only a role for GrM in the innate but also in the adaptive immune response. PMID: 19896187
11. GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity. PMID: 12506019
12. granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells PMID: 15028722
13. Granzyme (Gzm)M can directly degrade inhibitor of caspase-activated DNase (ICAD) to activate CAD, leading to DNA damage; GzmM cleaves DNA damage sensor enzyme poly(ADP-ribose) polymerase to prevent cellular DNA repair and force apoptosis. PMID: 16818775
14. Granzyme M targets major components of the cytoskeleton that likely contribute to natural killer (NK) cell-induced cell death. PMID: 18523284
15. NPM is essential for cell viability, these data suggest that targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function. PMID: 19103589
16. Structure-based mutagenesis reveals that the amino-terminus and catalytic triad of GzmM are most essential for proteolytic function. PMID: 19542453

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HGNC: 4712

OMIM: 600311

KEGG: hsa:3004

STRING: 9606.ENSP00000264553

UniGene: Hs.465511