Gdf5 Antibody

Datasheet
Code CSB-PA009349LA01MO
See More Details Free Antibody trial simple
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Uniprot No. P43027
Image
  • Immunohistochemistry of paraffin-embedded mouse liver tissue using CSB-PA009349LA01MO at dilution of 1:50

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA009349LA01MO at dilution of 1:20

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Mouse Growth/differentiation factor 5 protein (376-495AA)
Raised in Rabbit
Species Reactivity Mouse
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:10-1:100
Relevance Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14), Gdf5, Bmp14 Bp Gdf-5
Immunogen Species Mouse
Research Area Cardiovascular
Target Names Gdf5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8
Involvement in disease Defects in Gdf5 are the cause of brachypodism (bp) which alters the length and numbers of bones in the limbs but spares the axial skeleton.
Subcellular Location Secreted, Cell membrane
Protein Families TGF-beta family
Database Links

KEGG: mmu:14563

STRING: 10090.ENSMUSP00000048079

UniGene: Mm.4744

Pathway Hippo signaling pathway
TGF-beta signaling pathway

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