HAND2 Antibody

Code CSB-PA010126ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA010126ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010126ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) HAND2 Polyclonal antibody
Uniprot No. P61296
Target Names HAND2
Alternative Names AI225906 antibody; AI661148 antibody; autonomic nervous system and neural crest derivatives-expressed protein 2 antibody; Basic helix loop helix transcription factor HAND2 antibody; bHLHa26 antibody; Class A basic helix-loop-helix protein 26 antibody; Deciduum antibody; Deciduum heart autonomic nervous system and neural crest derivatives expressed protein 2 antibody; DHAND 2 antibody; dHAND antibody; DHAND2 antibody; Ehand 2 antibody; Ehand2 antibody; FLJ16260 antibody; HAND 2 antibody; Hand2 antibody; HAND2_HUMAN antibody; Heart and neural crest derivatives expressed 2 antibody; Heart and neural crest derivatives expressed protein 2 antibody; heart and neural crest derivatives expressed transcript 2 antibody; heart antibody; Heart- and neural crest derivatives-expressed protein 2 antibody; Hed antibody; Highly similar to dHAND M musculus antibody; MGC125303 antibody; MGC125304 antibody; Th 2 antibody; Th2 antibody; Thing 2 antibody; Thing2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Heart- and neural crest derivatives-expressed protein 2 protein (1-217AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).
Gene References into Functions
  1. Study showed that thalidomide inhibited the TBX5/HAND2 physical interaction, and the in silico docking revealed that the same amino acids involved in the interaction of TBX5 with DNA are also involved in its binding to HAND2. Results establish a HAND2/TBX5 pathway implicated in heart development and diseases. PMID: 28469241
  2. HAND2 mRNA and protein low expressed in endometrial carcinoma (EC) tissues, which suggested the degree of endometrial malignancy. PMID: 29767873
  3. The results identify HAND2 loci associated with susceptibility to early onset atrial fibrillation in a Korean population. PMID: 28460022
  4. These findings indicate that HAND2 loss-of-function mutation contributes to human CHD, perhaps via its interaction with GATA4 and NKX2.5. PMID: 26865696
  5. HAND2 and microRNA-1 facilitated the early progress of human induced cardiomyocyte-like cells reprogramming. PMID: 28796841
  6. this study is the first to report the association of a HAND2 loss-of-function mutation with an increased vulnerability to tetralogy of Fallot in humans, which provides novel insight into the molecular mechanism underpinning congenital heart disease PMID: 26676105
  7. HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha. PMID: 26166202
  8. suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells. PMID: 24745730
  9. Reduced protein expression of HAND2 in the myenteric plexus of the aganglionic segment would suggest that HAND2 was involved in the pathogenesis of Hirschsprung disease. PMID: 24210200
  10. Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to parallel a decrease in RNA and protein levels. PMID: 24265601
  11. Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q. PMID: 23449628
  12. No evidence of linkage between HAND2 and CL/P was obtained. Levelss of exclusion were obtained with different inheritance models. results did not support HAND2 in CL/P PMID: 21431856
  13. Expression analyses on both Hand2 conditionally null and hypomorphic backgrounds demonstrate that Hand2 is required for reporter activation in a gene dosage-dependent manner during sympathetic neurogenesis. PMID: 22323723
  14. Data suggest Hand2 plays an important role in decidualization; expression of Hand2 is significantly increased in response to prostaglandin E2. PMID: 21527398
  15. These data suggest that cytokines can inhibit norepinephrine transporter expression through downregulation of Hand2 or Gata3 in cultured sympathetic neurons, but axotomy in adult animals selectively suppresses Hand2 expression. PMID: 21241805
  16. Hand2 performs an essential role during transgenic epicardialization, directly impacting epicardial cell differentiation and formation of the coronary vasculature. PMID: 21350214
  17. HAND2 may be a potential candidate gene of stenosis of the right ventricle, outflow tract. PMID: 20819618
  18. dHAND/E-protein (E2A, ME2, and ALF1) heterodimers have distinct DNA binding specificities PMID: 15351717
  19. These results demonstrate the direct interactions of the Phox2a and b and dHAND transcription factors within a noradrenergic cell type PMID: 16280598
  20. demonstrate evolutionarily conserved functions of HAND transcription factors in Drosophila and mammalian cardiogenesis, and reveal a previously unrecognized requirement of Hand genes in hematopoiesis PMID: 16467358
  21. Hand2 plays a pivotal role in regulating both cell-autonomous and -nonautonomous functions of the cardiac neural crest. PMID: 19008477
  22. Expression of HAND2 and DEIN genes in neuroblastoma is co-regulated by asymmetrical activity of this promoter and modulated by the activity of two cis-regulatory elements acting as weak repressors PMID: 19348682

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Subcellular Location Nucleus
Tissue Specificity Heart.
Database Links

HGNC: 4808

OMIM: 602407

KEGG: hsa:9464

STRING: 9606.ENSP00000352565

UniGene: Hs.388245

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