HDAC11 Antibody

1. The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts. PMID: 29655790
2. Mycobacterium tuberculosis infection disturbs the HDAC6/HDAC11 levels to induce IL-10 expression in macrophages. PMID: 29523311
3. HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10. Hence, antagonizing HDAC11 activity may have anti-tumor potential, whereas activating HDAC11 may be useful to treat chronic inflammation or autoimmunity. PMID: 29222071
4. Results showed that the high levels of HDAC11 and lower levels of p53 were detected in pituitary tumor cells. A negative correlation was detected between the data of HDAC11 and p53. PMID: 28782861
5. Our study identified a group of cell cycle-promoting genes regulated by HDAC11. PMID: 28252645
6. High HDAC11 expression is associated with neoplasms. PMID: 23024001
7. Data indicate a pronounced deregulation of HDAC genes HDAC9 and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF). PMID: 21806350
8. These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L expression. PMID: 21239696
9. HDAC11 associates with replication origins inhibits Cdt1-induced re-replication and suppresses MCM loading. PMID: 20980834
10. We found a reduction of HDAC 11 mRNA and increased HDAC 2 levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls. PMID: 20467334
11. cloning and functional characterization PMID: 11948178
12. Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer. PMID: 16142391
13. the absence of tumour-specific somatic events in WNT7A and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours PMID: 17201809
14. HDAC11 negatively regulated expression of the gene encoding interleukin 10 in antigen-presenting cells. PMID: 19011628
15. Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11 PMID: 19276081

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HGNC: 19086

OMIM: 607226

KEGG: hsa:79885

STRING: 9606.ENSP00000295757

UniGene: Hs.744132