HDAC9 Antibody

Code CSB-PA010245KA01HU
Size US$398
Image
  • Western blot analysis of extracts of various cell lines, using HDAC9 antibody.
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Product Details

Uniprot No. Q9UKV0
Target Names HDAC9
Alternative Names HD 7 antibody; HD 7B antibody; HD 9 antibody; HD7 antibody; HD7B antibody; HD9 antibody; HDAC 7 antibody; HDAC 7B antibody; HDAC 9 antibody; HDAC 9B antibody; HDAC 9FL antibody; HDAC antibody; HDAC7 antibody; HDAC7B antibody; HDAC9 antibody; HDAC9_HUMAN antibody; HDAC9B antibody; HDAC9FL antibody; HDRP antibody; Histone deacetylase 4/5 related protein antibody; Histone deacetylase 7 antibody; Histone deacetylase 7B antibody; Histone deacetylase 9 antibody; Histone deacetylase 9A antibody; Histone deacetylase related protein antibody; Histone deacetylase-related protein antibody; KIAA0744 antibody; MEF2 interacting transcription repressor MITR antibody; MEF2 interacting transcription repressor protein antibody; MEF2-interacting transcription repressor MITR antibody; MITR antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen A synthetic peptide of Human HDAC9
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.; FUNCTION
Gene References into Functions
  1. This study highlights HDAC9 as a mediator of cell invasion and angiogenesis in Triple negative breast cancer (TNBC) cells through VEGF and MAPK3 by modulating miR-206 expression and suggests that selective inhibition of HDAC9 may be an efficient route for TNBC therapy. PMID: 29936177
  2. the T allele of rs2107595 in HDAC9 increases the risk of stroke but that the G allele of rs2389995 decreases the risk of stroke in the Chinese population (Meta-Analysis) PMID: 28145521
  3. HDAC9 may be a new indicator for assessing chronic heart failure. PMID: 30074176
  4. HDAC9 may be involved in the process of diabetic nephropathy. PMID: 27633396
  5. HDAC9, in cooperation with BRG1 and MALAT1, mediates a critical epigenetic pathway responsible for vascular smooth muscle cells dysfunction. PMID: 29520069
  6. M4 macrophages are a possible source for HDAC9 and MMP12 expression in advanced human carotid plaques. PMID: 28343758
  7. HDAC9 is an important epigenetic factor regulating ox-LDL-induced endothelial cell apoptosis and inflammatory factor expression. PMID: 27100479
  8. decline in HDAC9c expression over time was accompanied by increased EZH2 expression. PMID: 27250566
  9. HDAC9 might contribute to lymphomagenesis by altering pathways involved in growth and survival, as well as modulating BCL6 activity and p53 tumor suppressor function. PMID: 27799148
  10. post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates. PMID: 27312341
  11. Data show that the gene encoding the transcription factor SOX9 was identified by a global transcriptomic approach as an HDAC9 target gene. PMID: 26930713
  12. The minor allele A of SNP rs2107595 increased coronary artery disease risk and the severity of coronary atherosclerosis in a Chinese Han population. PMID: 27494404
  13. in leiomyosarcomas (LMS), this two-faced trait of MEF2 is relevant for tumor aggressiveness. Class IIa HDACs are overexpressed in 22% of LMS, where high levels of MEF2, HDAC4 and HDAC9 inversely correlate with overall survival. The knock out of HDAC9 suppresses the transformed phenotype of LMS cells, by restoring the transcriptional proficiency of some MEF2-target loci PMID: 28419090
  14. Based on this study, it is suggested that HDAC9 regulates the formation of APBs and could be a candidate for the target of ALT-cancer therapy. PMID: 27833022
  15. PC3/Tis21 associates with HDAC1, HDAC4, and HDAC9 in vivo, in fibroblast cells. PMID: 27333946
  16. HDAC9 is a target of miR-377 in oral squamous cell carcinoma. PMID: 28267394
  17. Studied HDAC9 gene's association with an increased susceptibility to acute coronary syndrome (ACS) in Chinese Han population. The results revealed a significant association of rs2240419 with ACS risk in which the A allele (P = 0.047) and the A allele carriers (AA + AG) (P = 0.037) were more likely to be in ACS group as compared to those in the control group. PMID: 27642596
  18. Downregulation of HDAC9 promotes gliomas. PMID: 27495233
  19. overexpression of HDAC9 contributes to OSCC carcinogenesis via targeting a transcription factor, MEF2D, and NR4A1/Nur77, a pro-apoptotic MEF2 target PMID: 26992905
  20. The aurora kinase A inhibited by MLN 8054 are both implicated in cell cycle progression and, thus, in cellular proliferation.Epigenetic regulators were targeted by SAHA inhibiting HDACs and by DZNep inhibiting the histone methyltransferase EZH2, which silences genes by trimethylating histone H3K27.Combinations of small molecular inhibitors act synergistically in rhabdoid tumor PMID: 27466490
  21. These results highlighting the significant correlation between TWIST and HDAC9 gene expression suggest that both genes may contribute to plaque stability in a coordinated way PMID: 26621503
  22. Polymorphisms of HDAC9 is associated with Ischemic Stroke. PMID: 26347468
  23. The results imply that HDAC9 is involved in the transcriptional regulation of human odontoblasts in vivo. PMID: 22297573
  24. HDAC9 was commonly expressed in retinoblastoma tissues and HDAC9 was overexpressed in prognostically poor retinoblastoma patients. PMID: 27033599
  25. HDAC9 promotes tumor formation of glioblastoma via TAZ-mediated EGFR pathway activation. PMID: 25760078
  26. the results of this study suggest that targeting HDACs by ST-3595 might represent as a novel and promising anti-pancreatic cancer strategy. PMID: 26084607
  27. results indicate that HDAC9 variant rs2107595 may be not associated with IS risk in southern Han Chinese PMID: 26093197
  28. Data show that miR-376a and HDAC9 expression are inversely correlated in hepatocellular carcinoma and suggest that HDAC9-mediated epigenetic modification may contribute to the down-regulation of the miR-376 cluster in hepatocellular carcinoma. PMID: 25613642
  29. Gene expression studies in peripheral blood mononuclear cells revealed increased mRNA levels of HDAC9. Analysis of human atherosclerotic plaques revealed no association between rs2107595 and specific plaque characteristics. PMID: 25388417
  30. The hydroxamic acid pan-HDAC inhibitor TSA synergistically inhibit the viability. PMID: 24562770
  31. The results elucidate the genetic etiology of lung adenocarcinoma by demonstrating that SNP rs10248565 in the HDAC9 gene may be a potential biomarker of cancer susceptibility. PMID: 24650256
  32. These results suggest that HDAC9 may be a suppressor and its downregulation might promote the progression process, especially in lung adenocarcinomas. PMID: 24427341
  33. study reports gene expression in skeletal muscle tissue of women with metabolic syndrome is enriched in inflammatory response-related genes; IL6R, HDAC9 and CD97 expression correlated negatively with insulin sensitivity; suggests a role for these 3 inflammatory genes in development of skeletal muscle insulin resistance in women PMID: 23771909
  34. These data suggest that HDAC9 variants may be selected for during cutaneous squamous cell carcinoma tumorigenesis PMID: 23784969
  35. In vivo sorafenib + HDAC inhibitor toxicity against tumors was increased. PMID: 23674352
  36. HDAC9 gene is significantly associated with large-vessel stroke risk in Chinese population. PMID: 23828597
  37. We propose that CtBP2 is an ovarian cancer oncogene that regulates gene expression program by modulating HDAC activity. PMID: 22945647
  38. SNP, rs12155400, in the histone deacetylase 9 gene (HDAC9) on chromosome 7, was associated with retinopathy in analysis of participants without hypertension PMID: 23393555
  39. Our results are consistent with the 7p21.1 association acting via promoting atherosclerosis, and consistent with alterations in HDAC9 expression mediating this increased risk. PMID: 23449258
  40. Regression models consistently identified rs2522129, rs2675231, and rs2389963 as having among the highest predictive values for explaining differences related to brain volume measures PMID: 22884548
  41. Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases HDAC4, 5 and 9 PMID: 23297420
  42. HDAC9 promotes angiogenesis and transcriptionally represses the endothelial cell miR-17-92 cluster. PMID: 23288173
  43. LBH589 and TSA may translationally regulate some HDAC encoding genes in pancreatic tumors. PMID: 22487525
  44. Data indicate a pronounced deregulation of HDAC genes HDAC9 and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF). PMID: 21806350
  45. We identified a new association for large vessel stroke within HDAC9 on chromosome 7p21.1. PMID: 22306652
  46. Treated the seminoma-like cell line TCam-2 with the HDAC-inhibitor Depsipeptide. PMID: 21987446
  47. The results show that hdac9 is the third androgenic alopecia susceptibility gene PMID: 22032556
  48. HDAC9 acts as an epigenetic switch in effector T cell-mediated systemic autoimmunity. PMID: 21708950
  49. HDAC suppresses the activation of PPARgamma in the gastric carcinoma cell line SGC-7901. PMID: 19624894
  50. MITR plays a master switch role to balance osteogenic and adipogenic differentiation of MSCs through regulation of PPARgamma-2 transcriptional activity. PMID: 21247904
  51. Histone deacetylases 9 and 10 are required for homologous recombination. PMID: 21247901
  52. enforced HDAC9 expression increased gamma-globin mRNA levels by 2.5-fold with a simultaneous 7-fold increase in HbF. PMID: 21078662
  53. Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein PMID: 20947501
  54. Chromosomal organization on chromsome 7 PMID: 12054582
  55. ICP0 of Herpes simplex virus Type 1 interacts with and controls the repressor activity of class II HDAC7 PMID: 15194749
  56. The crystal structure of a histone deacetylase 9 (HDAC9)/myocyte enhancer factor-2 (MEF2)/DNA complex reveals that HDAC9 binds to a hydrophobic groove of the MEF2 dimer. PMID: 15567413
  57. Moraxella catarrhalis-induced cytokine expression is regulated by acetylation of histone residues and controlled by histone deacetylase activity. PMID: 16399788
  58. The role of ACTN4 in MEF2A transcription via HDAC7 antagonism is reported. PMID: 16980305
  59. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression PMID: 17360565
  60. Endogenous HDAC activity plays a crucial role in maintaining the balance of pre-established T(H)1-like and T(H)2-like responses, inhibiting excessive T(H)2 immunity. PMID: 17980413
  61. amino enhancer of split has apoptotic activity in neurons and suggest that neuroprotection by histone deacetylase-related protein is mediated by the inhibition of this activity through direct interaction. PMID: 18438919
  62. Analysis of chromatin modification patterns shows that HDAC are recruited to the c-myc promoter leading to appearance of repressive chromatin marks. PMID: 19522008
  63. Results demonstrate that histone deacetylase inhibitors (HDACIs) in different combinations with RA, act as cell growth inhibitors. PMID: 19723072

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Involvement in disease A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein.
Subcellular Location Nucleus
Protein Families Histone deacetylase family, HD type 2 subfamily
Tissue Specificity Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
Database Links

HGNC: 14065

OMIM: 606543

KEGG: hsa:9734

STRING: 9606.ENSP00000408617

UniGene: Hs.196054

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