Code | CSB-RA010245A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IF | 1:20-1:200 |
CUSABIO cloned HDAC9 antibody-coding genes into plasma vectors and then transfected these vector clones into mammalian cells using a lipid-based transfection reagent. Following transient expression, the recombinant antibodies against HDAC9 were harvested and characterized. The recombinant HDAC9 antibody was purified by affinity-chromatography from the culture medium. It can be used to detect HDAC9 protein from Human in the ELISA, WB, IHC, IF.
HDAC9 is an enzyme responsible for the removal of acetyl moieties from the ϵ-amino groups of conserved lysine residues in the N-terminal tail of histones. HDAC9 can freely move between the nucleus and the cytoplasm and interacts with histone and non-histone substrates to facilitate tissue-specific transcriptional control. Biologically, HDAC9 regulates a wide range of physiological functions in both normal and diseased states, including cardiac muscle development, bone formation, T-regulatory cell function, neurological diseases, muscle differentiation, adipocyte differentiation, and cancer. HDAC9 overexpression is also prevalent in cancer cells, where it affects the expression and function of a number of key proteins involved in cancer development.
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