HELLS Antibody

1. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex; immunodeficiency-centromeric instability-facial anomalies syndrome has a defective HELLS and CDCA7 bipartite nucleosome remodeling complex PMID: 29339483
2. This study elucidates the molecular basis of the c-Myc/EGLN1-mediated induction of LSH expression that inhibits ferroptosis PMID: 28900510
3. LSH is likely one of the mechanisms of genome instability underlying 5-hydroxymethylcytosine loss in cancer. PMID: 29109788
4. High mRNA levels of HELLS is independent predictor of poor outcome in Renal Cell Carcinoma patients. PMID: 28069330
5. Mutations in HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome type 4. PMID: 26216346
6. Mutations of HELLS gene is associated with stomach and colorectal cancers. PMID: 25351940
7. Upregulation of HELLS and UHRF1 is essential for the tumor phenotype. Also, these epigenetic regulators are important for the regulation of SYK. PMID: 25338120
8. just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours PMID: 22157815
9. E2F1 plays a crucial role in transcriptional control of the human Lsh gene and the decrease of Lsh expression in senescent cells is related to the repression of E2F1 PMID: 21453717
10. Data provide strong evidence that CEP55 and HELLS may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression. PMID: 20400365
11. LSH serves as a recruiting factor for DNA methyltransferases and histone deacetylases to establish transcriptionally repressive chromatin which is perhaps further stabilized by DNA methylation at targeted loci PMID: 17967891
12. These results suggest differences in cellular consequences of hypomethylation mediated by PASG during development compared to that in somatic cells. PMID: 18948754
13. Lsh overexpression delays cell senescence by silencing p16(INK4a) in human fibroblasts. PMID: 19561196

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HGNC: 4861

OMIM: 603946

KEGG: hsa:3070

STRING: 9606.ENSP00000239027

UniGene: Hs.463677