HES7 Antibody, HRP conjugated

Code CSB-PA887160LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HES7 Polyclonal antibody
Uniprot No.
Target Names
HES7
Alternative Names
bHLH factor Hes7 antibody; bHLHb37 antibody; Class B basic helix loop helix protein 37 antibody; Class B basic helix-loop-helix protein 37 antibody; Hairy and enhancer of split 7 antibody; hes family bHLH transcription factor 7 antibody; Hes7 antibody; HES7_HUMAN antibody; hHes7 antibody; SCDO4 antibody; Transcription factor HES 7 antibody; Transcription factor HES-7 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription factor HES-7 protein (127-192AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.
Gene References into Functions
  1. mutation of HES7 is uniquely associated with defects in vertebral, heart and neural tube formation, and this observation will help provide a discriminatory diagnostic guide in patients with SCD, as well as inform molecular genetic testing. PMID: 23897666
  2. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population. PMID: 22744456
  3. Two new missense mutations in HES7 in a family with spondylocostal dysostosis. PMID: 20087400
  4. R25W missense mutation of HES7 is causative of Spondylocostal dysostosis. PMID: 18775957
Involvement in disease
Spondylocostal dysostosis 4, autosomal recessive (SCDO4)
Subcellular Location
Nucleus.
Database Links

HGNC: 15977

OMIM: 608059

KEGG: hsa:84667

STRING: 9606.ENSP00000446205

UniGene: Hs.434828

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