HIPK1 Antibody, HRP conjugated

1. HIPK1, HIPK2 and HIPK3 interact with the components of the carbon catabolite repressor 4 (CCR4)-negative on TATA (NOT) complex, an important regulator of all the major steps in the mRNA metabolism. it has emerged that HIPKs and their related miRNAs are involved in diabetic nephropathy, gastric cancer chemoresistance, cervical cancer progression, and recombinant protein expression in cultured cells. [Review] PMID: 29793420
2. The data presented here con fi rmed that HIPK1 is involved in the increased expression of recombinant luciferase and the secreted recombinant GPC3-hFc from HEK 293 cells following transfection with miR-22-3p. PMID: 28987030
3. PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1. PMID: 24559171
4. HIPK1 drives p53 activation to limit colorectal cancer cell growth. PMID: 23676219
5. HIPK1 and HIPK2, are transcriptional corepressors that regulate TGF-beta-dependent angiogenesis during embryonic development. PMID: 23565059
6. HIPK1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear. PMID: 23071292
7. TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha-induced ASK1-JNK/p38 activation PMID: 15701637
8. c-Myb appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data. PMID: 19646965

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HGNC: 19006

OMIM: 608003

KEGG: hsa:204851

STRING: 9606.ENSP00000358571

UniGene: Hs.532363