Product Details

Uniprot No.

Target Names

HM13

Alternative Names

dJ324O17.1 antibody; H13 antibody; hIMP1 antibody; Histocompatibility (minor) 13 antibody; HM13 antibody; HM13_HUMAN antibody; IMP-1 antibody; IMP1 antibody; IMPAS antibody; IMPAS-1 antibody; Intramembrane protease 1 antibody; Intramembrane protease antibody; Minor histocompatibility antigen 13 antibody; Minor histocompatibility antigen H13 antibody; MSTP086 antibody; OTTHUMP00000030527 antibody; OTTHUMP00000030528 antibody; OTTHUMP00000030530 antibody; OTTHUMP00000214528 antibody; Presenilin-like protein 3 antibody; PSENL3 antibody; PSL3 antibody; Signal peptide peptidase antibody; Signal peptide peptidase beta antibody; SPP antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Human HM13

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection.

Gene References into Functions

Preproinsulin signal peptide epitopes are processed by SPP and loaded for HLA-guided immune recognition via pathways that are enhanced during type 1 diabetes pathogenesis. PMID: 29343547
Though far from complete, our knowledge on pathophysiological functions of SPP/SPPL proteases, in particular based on studies in mice, has been significantly increased over the last years. Based on this, inhibition of distinct SPP/SPPL proteases has been proposed as a novel therapeutic concept e.g. for the treatment of autoimmunity and viral or protozoal infections, as we will discuss in this review. PMID: 28624439
The domains involved in HO-1 translocation have been identified, and it was shown that SPP-mediated HO-1 cleavage is isoform-specific (HO-1 vs HO-2) and independent of heme oxygenase activity. PMID: 29155886
This study identifies that SPP affects EGFRvIII secretion profiles and thus promotes tumor progression, providing further understanding of the formation of secreted vesicles and driving role of EGFRvIII in Glioblastoma. PMID: 28198167
structure of human SPP [SPP] PMID: 21636854
identified human signal peptide peptidase as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases [SPP] PMID: 12077416
identification and molecular cloning; expression analysis of the hIMP1 gene (located on chromosome 20) was performed in human cell tissues and transfected cell cultures [IMP1] PMID: 12139484
widespread expression of SPP in many tissues PMID: 12972007
signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor PMID: 14704149
IMP1 is a bi-aspartic polytopic protease capable of cleaving transmembrane proteins such as presenilin 2. PMID: 14741365
The peptide structure corresponding to the C-terminal residues from H13 ribosomal protein was determined using magnetic resonance spectroscopy. PMID: 14988012
data implicate SPP in the US2 pathway and indicate the possibility of a previously unknown function for this intramembrane-cleaving aspartic protease in dislocation from the endoplasmic reticulum PMID: 16738546
Upon isolation of membranes and solubilization with detergent, the biochemical characteristics of SPP are remarkably similar to gamma-secretase. PMID: 16834339
Compares a variant from the mouse ortholog to the human gene. PMID: 16730383

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Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.; [Isoform 4]: Cell membrane; Multi-pass membrane protein.

Protein Families

Peptidase A22B family

Tissue Specificity

Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.

Database Links

HGNC: 16435

OMIM: 607106

KEGG: hsa:81502

UniGene: Hs.373741