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Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres.
Gene References into Functions
Low HMBOX1 expression is associated with liver cancer progression. PMID: 30015890
HMBOX1 played important role in the high-grade serous ovarian cancer through regulation of proliferation and apoptosis. PMID: 29709478
HMBOX1 may be a potential diagnostic marker in glioma. PMID: 28731165
Our data suggest a possible role of HMBOX1 in regulating radiosensitivity in cervical cancer cells. PMID: 28628186
HMBOX1 regulates intracellular free zinc level by interacting with MT2A to inhibit apoptosis and promote autophagy in vascular endothelial cells. PMID: 26456220
a homeobox-containing protein known as HMBOX1 can directly bind telomeric double-stranded DNA and associate with PML nuclear bodies. PMID: 23813958
our results revealed a novel regulatory mechanism: miR-30c-1(*) promoted NK cell cytotoxicity against hepatoma cells by targeting HMBOX1. PMID: 22320217
HMBOX1 may function as a negative regulator of IFN-gamma in NK cells. PMID: 21839858
HMBOX1 negatively regulates the expression of NKG2D and the activation of the NKG2D/DAP10 signaling pathway in NK cells. PMID: 21706044
higher HMGB1(homeobox containing 1) levels in Tracheal aspirates are associated with the development of bronchopulmonary dysplasia or death in ventilated premature infants. PMID: 20182437
These findings suggest a distinct role of HMBOX1b, and the control of mRNA splicing might be involved in homeobox genes regulation. PMID: 19757162
decreased expression in hepatic carcinoma PMID: 19728927
Hmbox1 is widely expressed in pancreas and the expression of this gene can also be detected in pallium, hippocampus and hypothalamus PMID: 16825764