HOXA5 Antibody

Code CSB-PA010655LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western Blot
    Positive WB detected in: SH-SY5Y whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate, Rat heart tissue
    All lanes: HOXA5 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 30 kDa
    Observed band size: 49 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA010655LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) HOXA5 Polyclonal antibody
Uniprot No. P20719
Target Names HOXA5
Alternative Names Homeo box 1C antibody; Homeo box A5 antibody; Homeobox A5 antibody; Homeobox protein Hox-1C antibody; Homeobox protein Hox-A5 antibody; Homeobox protein HOXA5 antibody; HOX 1 antibody; HOX 1.3 antibody; HOX 1C antibody; HOX1 antibody; HOX1.3 antibody; HOX1C antibody; HOXA5 antibody; HXA5_HUMAN antibody; MGC9376 antibody; OTTHUMP00000217259 antibody
Raised in Rabbit
Species Reactivity Human, Rat
Immunogen Recombinant Human Homeobox protein Hox-A5 protein (1-270AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
Gene References into Functions
  1. HOXA5 functions as a tumor suppressor in regulating tumor growth of gastric cancer (GC) under regulation of miR-196a, supporting its potential utility as a therapeutic target for GC. PMID: 30267809
  2. LncRNA GAS5 depressed OA development by targeting miR-196a-5p and thereby down-regulating HOXA5 expression, providing substance for developing lncRNA-based strategies to treat OA. PMID: 30201235
  3. Low HOXA5 expression is associated with Gastric cancer. PMID: 30015922
  4. Research demonstrated that depletion of HOXA5 inhibited osteogenic differentiation and repressed cell proliferation by arresting cell cycle progression at the S phase via p16(INK4A) , p18(INK4C) , and Cyclin A in SCAPs, indicating that HOXA5 has a significant role in maintaining the proliferation and differentiation potential of dental-tissue-derived MSCs. PMID: 28833816
  5. The study demonstrated that MPP8 was associated with non-small cell lung cancer cell proliferation through regulation of HOXA5. PMID: 29412790
  6. The present study demonstrates that HOXA5 can be silenced in the psoriatic stratum corneum due to DNA methylation of the CGI located in the 5' region of HOXA5. PMID: 28482119
  7. study implicates HOXA5 as a chromosome 7-associated gene-level locus that promotes selection for gain of whole chromosome 7 and an aggressive phenotype in glioblastoma. PMID: 29632085
  8. HOXA5 could bind in the promoter of linc00312 and up-regulated the expression of it. PMID: 28338293
  9. HOXA5 was identified as a tumor suppressor gene, which inhibited non-small-cell lung cancer metastasis by regulating cytoskeletal remodeling. Its expression is repressed by linc00673 through binding with EZH2. PMID: 28423732
  10. lung cancer stem-like cells have plasticity under a condition of oxidative stress, and HOAX5 has a critical role in dedifferentiation PMID: 27418136
  11. loss of HOXA5 in mammary cells leads to loss of epithelial traits, an increase in stemness and cell plasticity, and the acquisition of more aggressive phenotypes. PMID: 27157614
  12. ATRA may inhibit the proliferation of K562 cells and promote apoptosis by upregulating the HOXA5 mRNA and protein expression. PMID: 27052693
  13. Knockdown of HOXA5 suppressed the proliferation and metastasis of esophageal squamous cell cancer cells. PMID: 27960137
  14. high expression levels of HOXA5 mRNA and protein in children with ALL indicate that HOXA5 is closely associated with childhood ALL. PMID: 26846409
  15. Downregulation of HOXA5 by shRNA may trigger apoptosis and overcome drug resistance in leukemia cells. PMID: 26397212
  16. HOXA5-induced apoptosis was p53-independent. PMID: 26219418
  17. Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3, contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review) PMID: 25979369
  18. In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis. PMID: 26678341
  19. Ectopic expression of HOXA5 in highly invasive cancer cells suppressed cell migration, invasion, and filopodia formation in vitro and inhibited metastatic potential in vivo. PMID: 25875824
  20. Increased expression of HOXA5 is associated with acute myeloid leukemia. PMID: 25987065
  21. Our findings present that decreased HOXA5 could be identified as a poor prognostic biomarker in nonsmall cell lung cancer and regulate cell proliferation and invasion PMID: 25549794
  22. miR-1271 regulates non-small-cell lung cancer cell proliferation and invasion, via the down-regulation of HOXA5. PMID: 25686496
  23. Our analysis showed that miR-196a suppressed the expression of HOXA5 both at the mRNA and protein levels; knockdown of HOXA5 expression in A549 cells using RNAi was shown to promote NSCLC cell proliferation, migration and invasion. PMID: 22876840
  24. HOXA5 can suppress keratinocytes growth and epidermal formation. PMID: 22464764
  25. since lower levels of HOXA5 predict poor prognosis, this gene may be a novel candidate for development of therapeutic strategies in OSCC. PMID: 22227861
  26. Androgen receptor mutations are associated with altered epigenomic programming as evidenced by HOXA5 methylation. PMID: 21311178
  27. The methylation percentage of HOXA5 in AML patients was higher than that of HOXA5 in control patients. PMID: 20890077
  28. HOXA5 is hypermethylated in clear cell renal cell carcinoma. PMID: 20846263
  29. engineered a p53-mutant breast cancer cell line, Hs578T, to inducibly express HOXA5. Expression of HOXA5 can induce apoptosis through an apoptotic mechanism mediated by caspases 2 and 8. PMID: 14701762
  30. loss of HOXA5 expression could lead to the functional activation of Twist resulting in aberrant cell cycle regulation and promoting breast carcinogenesis PMID: 15545268
  31. analysis of transcriptional targets of HOXA5 by microarray hybridization PMID: 15757903
  32. Hox A5 expression is inconsistent with an angiogenic phenotype; expression of Hox A5 may help to maintain existing vessels in a quiescent, differentiated state. PMID: 16379594
  33. HOXA5 is a transcriptional regulator of hMLH1 in breast cancer cells PMID: 16756717
  34. HOXA5 expression was maintained at stable levels at different reproductive stages of a woman's life, except during lactation. HOXA5 protein expression levels in breast carcinomas inversely co-relates with Epidermal Growth Factor Receptor expression. PMID: 17167183
  35. Study identified hypermethylation and gene inactivation of HOXA4 and HOXA5 was frequently observed (26-79%) in all types of leukemias studied. PMID: 17785556
  36. HOXA5 acts directly downstream of RARbeta and may contribute to retinoid-induced anticancer and chemopreventive effects. PMID: 17804711
  37. miR-130a is a regulator of the angiogenic phenotype of vascular endothelial cells largely through its ability to modulate the expression of GAX and HOXA5 PMID: 17957028
  38. The promoter methylation status of a panel of critical growth regulatory genes, RASSF1A, RARbeta2, BRCA1 and HOXA5, in 54 breast cancers and 5 distant normal breast tissues of Indian patients, was analyzed. PMID: 18538349
  39. Epigenetic inactivation of Homeobox A5 gene is associated with nonsmall cell lung cancer. PMID: 19554572

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Subcellular Location Nucleus
Protein Families Antp homeobox family
Database Links

HGNC: 5106

OMIM: 142952

KEGG: hsa:3202

STRING: 9606.ENSP00000222726

UniGene: Hs.655218

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