HOXB3 Antibody, HRP conjugated

Code CSB-PA010663LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HOXB3 Polyclonal antibody
Uniprot No.
Target Names
HOXB3
Alternative Names
Homeo box 2G antibody; Homeo box B3 antibody; Homeobox B3 antibody; Homeobox protein Hox-2.7 antibody; Homeobox protein Hox-2G antibody; Homeobox protein Hox-B3 antibody; Homeobox protein HoxB3 antibody; Hox 2.7 antibody; HOX 2G antibody; HOX2 antibody; Hox2.7 antibody; HOX2G antibody; HOXB3 antibody; HXB3_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Homeobox protein Hox-B3 protein (315-423AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Gene References into Functions
  1. Data indicate a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggest a therapeutic strategy of restoring miR-375 expression in Acute myeloid leukemia (AML). PMID: 29439669
  2. HOXB3 is degraded by miR-375 in breast cancer cells.HOXB3 plays role in tamoxifen resistance. PMID: 28075453
  3. miR-10b might control cell apoptosis, proliferation, migration, and invasion in endometrial cancer via regulation of HOXB3 expression. PMID: 27447302
  4. decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML, while increased DNA methylation at DCC distinctive to the high-risk AML was associated with increased gene expression PMID: 25996682
  5. describe familial cases of TH in two generations (proband and his father), in addition to other two sporadic cases. We have found polymorphisms in the HOXB3, HOXD3, and a new synonymous variant, and PITX2 genes PMID: 24127533
  6. HoxB3 promote prostate cancer progression by upregulating CDCA3 expression. PMID: 23219899
  7. The HOXb3 was only weakly expressed in the inv(7) positive patients. PMID: 15674412
  8. RASSF1A silencing strongly correlates with overexpression of HOXB3 and DNMT3B. PMID: 19854132

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family
Database Links

HGNC: 5114

OMIM: 142966

KEGG: hsa:3213

STRING: 9606.ENSP00000308252

UniGene: Hs.654560

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