HOXD3 Antibody

1. The findings indicate that miR-203a inhibits hepatocellular carcinoma cell invasion, metastasis, and angiogenesis by negatively targeting HOXD3 and suppressing cell signaling through the VEGFR pathway. PMID: 29402992
2. EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways. PMID: 27244890
3. the HOXD3 gene promotes colorectal cancer cell growth and plays a pivotal role in the development and survival of malignant human colorectal cancer cells. PMID: 27499213
4. These results validate the association between promoter hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence PMID: 24718283
5. HOXD3 promoter hypermethylation is correlated with clinicopathologic features in prostate cancer. This correlation is more common in older, higher risk patients. PMID: 24847526
6. High expression of HOXD3 correlates with invasive breast cancer. PMID: 22935821
7. quantitative increase in promoter methylation levels of HOXD3 is associated with prostate cancer progression PMID: 21207416
8. HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones. PMID: 20212450
9. transduction of antisense DNA into human melanoma cells results in decreased invasive and motile activities PMID: 12405287
10. Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo. PMID: 14610084
11. HoxD3 may provide a means to directly improve collagen deposition, angiogenesis and closure in poorly healing diabetic wounds. PMID: 14633614
12. HOXD3 may play an important role in regulating cerebral angiogenesis, and that gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis PMID: 15545924
13. The karyotype of our patient suggests another possible locus of the Duane syndrome, and the mapped genes around the deleted region, 1q42.13-43, contain possible candidate genes such as a homeobox gene. PMID: 17126050
14. Further validation of candidate genes on a separate cohort of low and high grade prostate cancers by quantitative MethyLight analysis has allowed us to confirm DNA hypermethylation of HOXD3 and BMP7... PMID: 19283074

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HGNC: 5137

OMIM: 142980

KEGG: hsa:3232

STRING: 9606.ENSP00000249440

UniGene: Hs.93574