HOXD3 Antibody

Code CSB-PA010686LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Jurkat whole cell lysate, K562 whole cell lysate, SH-SY5Y whole cell lysate, Rat brain tissue
    All lanes: HOXD3 antibody at 8.5μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 46 kDa
    Observed band size: 46 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HOXD3 Polyclonal antibody
Uniprot No.
Target Names
HOXD3
Alternative Names
Homeo box D3 antibody; Homeobox D3 antibody; Homeobox protein Hox D3 antibody; Homeobox protein Hox-4A antibody; Homeobox protein Hox-D3 antibody; Homeobox protein HoxD3 antibody; Homeodomain protein antibody; HOX 1D antibody; HOX 4 antibody; Hox 4.1 antibody; Hox 4A antibody; HOX D3 antibody; Hox-4.1 mouse homolog of antibody; HOX1D antibody; HOX4 antibody; Hox4.1 antibody; HOX4A antibody; HOXD 3 antibody; HOXD3 antibody; HXD3_HUMAN antibody; MGC10470 antibody
Raised in
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant Human Homeobox protein Hox-D3 protein (263-346AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The HOXD3 Antibody (Product code: CSB-PA010686LA01HU) is Non-conjugated. For HOXD3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA010686LB01HU HOXD3 Antibody, HRP conjugated ELISA
FITC CSB-PA010686LC01HU HOXD3 Antibody, FITC conjugated
Biotin CSB-PA010686LD01HU HOXD3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Gene References into Functions
  1. The findings indicate that miR-203a inhibits hepatocellular carcinoma cell invasion, metastasis, and angiogenesis by negatively targeting HOXD3 and suppressing cell signaling through the VEGFR pathway. PMID: 29402992
  2. EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways. PMID: 27244890
  3. the HOXD3 gene promotes colorectal cancer cell growth and plays a pivotal role in the development and survival of malignant human colorectal cancer cells. PMID: 27499213
  4. These results validate the association between promoter hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence PMID: 24718283
  5. HOXD3 promoter hypermethylation is correlated with clinicopathologic features in prostate cancer. This correlation is more common in older, higher risk patients. PMID: 24847526
  6. High expression of HOXD3 correlates with invasive breast cancer. PMID: 22935821
  7. quantitative increase in promoter methylation levels of HOXD3 is associated with prostate cancer progression PMID: 21207416
  8. HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones. PMID: 20212450
  9. transduction of antisense DNA into human melanoma cells results in decreased invasive and motile activities PMID: 12405287
  10. Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo. PMID: 14610084
  11. HoxD3 may provide a means to directly improve collagen deposition, angiogenesis and closure in poorly healing diabetic wounds. PMID: 14633614
  12. HOXD3 may play an important role in regulating cerebral angiogenesis, and that gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis PMID: 15545924
  13. The karyotype of our patient suggests another possible locus of the Duane syndrome, and the mapped genes around the deleted region, 1q42.13-43, contain possible candidate genes such as a homeobox gene. PMID: 17126050
  14. Further validation of candidate genes on a separate cohort of low and high grade prostate cancers by quantitative MethyLight analysis has allowed us to confirm DNA hypermethylation of HOXD3 and BMP7... PMID: 19283074

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family
Database Links

HGNC: 5137

OMIM: 142980

KEGG: hsa:3232

STRING: 9606.ENSP00000249440

UniGene: Hs.93574

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