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HPS3 Antibody

Datasheet
Code CSB-PA010712GA01HU
Size $600
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Product Details

Uniprot No.
Q969F9
Target Names
HPS3
Alternative Names
HPS3 antibody; Hermansky-Pudlak syndrome 3 protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human HPS3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in early stages of melanosome biogenesis and maturation.
Gene References into Functions
  1. HPS3 mutation is associated with high hypopigmentation in Hermansky-Pudlak syndrome. PMID: 27593200
  2. Description of mutations in HPS genes that cause Hermansky-Pudlak syndrome (review) PMID: 12125811
  3. HPS4 but not HPS3 associates with HPS1 in a complex, which we term biogenesis of lysosome-related organelles complex 3 (BLOC-3) PMID: 12847290
  4. A specific subset of melanocyte proteins are aberrantly trafficked throughout the HPS-3 melanocyte and may be responsible for the reduction in melanin synthesis. PMID: 15632015
  5. HPS3 associates with clathrin, predominantly on small clathrin-containing vesicles in the perinuclear region. This association most likely occurs directly via a functional clathrin-binding domain in HPS3. PMID: 16159387
  6. mutational analysis in Ashkenazi Jews with Hermansky-Pudlak syndrome 3 PMID: 11590544

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Involvement in disease
Hermansky-Pudlak syndrome 3 (HPS3)
Subcellular Location
Cytoplasm. Cytoplasm, cytosol.
Tissue Specificity
Widely expressed. Higher levels of expression are observed in kidney, liver and placenta.
Database Links

HGNC: 15597

OMIM: 606118

KEGG: hsa:84343

STRING: 9606.ENSP00000296051

UniGene: Hs.558314

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