HSD17B6 Antibody

Datasheet

Code	CSB-PA304268
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA304268(HSD17B6 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA304268(HSD17B6 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Target Background

Product Details

Uniprot No.

O14756

Target Names

HSD17B6

Alternative Names

17-beta-HSD 6 antibody; 17-beta-HSD6 antibody; 17-beta-hydroxysteroid dehydrogenase type 6 antibody; 3 hydroxysteroid epimerase antibody; 3(alpha >beta) hydroxysteroid epimerase antibody; 3(alpha >beta) hydroxysteroid epimerasel antibody; 3-alpha->,beta-HSE antibody; 3-alpha->,beta-hydroxysteroid epimerase antibody; H17B6_HUMAN antibody; HSD17B6 antibody; HSE antibody; Hydroxysteroid (17 beta) dehydrogenase 6 antibody; Hydroxysteroid (17 beta) dehydrogenase 6 homolog (mouse) antibody; Hydroxysteroid 17 beta dehydrogenase 6 antibody; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase antibody; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase antibody; Oxidative 3 alpha hydroxysteroid dehydrogenase antibody; Oxidative 3-alpha hydroxysteroid dehydrogenase antibody; Oxidoreductase antibody; Retinol dehydrogenase antibody; RODH antibody; SDR9C6 antibody; Short chain dehydrogenase/reductase family 9C, member 6 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human HSD17B6

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.

Gene References into Functions

No significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 and rs898611 of HSD17B6 between patients with PCOS and controls. PMID: 25422294
the CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower. PMID: 24244276
data suggest that there is no association of HSD17B6 and HSD17B5 variants with the occurrence of polycystic ovary syndrome in the Chinese population PMID: 21039282
17beta-hydroxysteroid dehydrogenase type 6 (17betaHSD6) converts the androgen DHT to the estrogen 3beta-Adiol, and this leads to activation of the ERbeta reporter. PMID: 22114194
These data suggest that polymorphisms in the HSD17B6 gene are associated with PCOS and key clinical phenotypes of the disorder. PMID: 17070195
RoDH enzymes are expressed in tissues that have microsomal 3alpha-hydroxysteroid dehydrogenase/epimerase activities PMID: 17289849
These replication data suggest a role for HSD17B6 in polycystic ovary syndrome PMID: 19837928

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Subcellular Location

Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side.

Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Tissue Specificity

Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosu

Database Links

HGNC: 23316

OMIM: 606623

KEGG: hsa:8630

STRING: 9606.ENSP00000318631

UniGene: Hs.524513

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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