HSPBP1 Antibody

1. Findings indicate a critical role of HspBP1 in differential CHIP/Hsp70 activities in neuronal and glial cells and the greater neuronal vulnerability to misfolded proteins in neurodegenerative diseases. PMID: 28847953
2. downregulation of Hsp70 and HspBP1 represents a unique feature of patients with preterm prelabor rupture of membranes PMID: 28497897
3. our results clearly show that HspBP1 acts as an endogenous negative regulator of HIV-1 gene-expression and replication by suppressing NF-kappaB-mediated activation of viral transcription. PMID: 26538602
4. Oxidative stress, inducing formation of disulfide bond, can affect stability and conformational mobility of human HspB1. PMID: 24898092
5. BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes PMID: 24454860
6. shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing formation of the cytotoxic Tag7-Hsp70 complex PMID: 22037021
7. High gene expression of HspBP1 is associated with leukemia. PMID: 20694586
8. Results report cooperative interactions involving Hsp70, Hsp40, and TPR1 that enhance Hsp70-dependent folding of chemically denatured substrates. PMID: 14503850
9. Detection of hsp70 may be used as the screening marker for diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer related lung cancer, and may supplement the diagnostic value of conventional cytology. PMID: 14761400
10. BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP PMID: 16169850
11. The results demonstrate that Hsp70 and HspBP1 are not coordinately regulated but provide evidence that an increase in the ratio of HspBP1 to Hsp70 correlates with apoptosis, in a similar way to reducing the amount of Hsp70. PMID: 16677834
12. Stress-induced heat shock protein 70 (Hsp70) effectively protects cells against ultraviol ray-induced apoptosis in melanocytes bu penetrating mitchondrial and lysosomal membranes. PMID: 16950797
13. Here, we report that upon the formation of huntingtin aggregates; endogenous cytosolic huntingtin, Hsc70/Hsp70 (heat shock protein and cognate protein of 70kDa) and syntaxin 1A become aggregate-centered. PMID: 17208201
14. that HspBP1, by antagonizing the prosurvival activity of Hsp70, sensitizes tumor cells to cathepsin-mediated cell death. PMID: 17855353
15. Association between endogenous LAP2alpha and Hsp70 in non-transfected cells was confirmed by co-immunoprecipitation. PMID: 18261988
16. The two chaperones, HSP72 and HSPBP1, interact both physically and functionally, leading to the activation of th EGFR-ERK1/2 signalling pathway. PMID: 18986301
17. Results indicate that low HspBP1 expression could be a marker of tumor aggressiveness. PMID: 18987994
18. Our data suggest that HIP may prevent inclusion formation by facilitating the constitutive HSC70 refolding cycle and possibly by preventing aggregation. PMID: 19183265
19. HspBP1 may play a role in tumor (dys)regulation of chaperone proteins PMID: 19659607
20. The cochaperone HspBP1 binds to and inhibits Hsp70 activity. PMID: 9830037

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HGNC: 24989

OMIM: 612939

KEGG: hsa:23640

STRING: 9606.ENSP00000255631

UniGene: Hs.53066