HTN3 Antibody

Code CSB-PA010879NA01HU
Size US$166
Order now
Image
  • IHC image of CSB-PA010879NA01HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HTN3 Polyclonal antibody
Uniprot No.
Target Names
HTN3
Alternative Names
HTN3 antibody; HIS2 antibody; Histatin-3 antibody; Basic histidine-rich protein antibody; Hst antibody; Histidine-rich protein 3 antibody; PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide antibody; His3 20/44 antibody; His3-(1-25)-peptide antibody; His3 1/25 antibody; Histatin-3 1/25 antibody; Histatin-6); His3-(20-43)-peptide antibody; His3 20/43 antibody; His3-(1-24)-peptide antibody; His3 1/24 antibody; Histatin-3 1/24 antibody; Histatin-5); His3-(20-32)-peptide antibody; His3 20/32 antibody; His3-(1-13)-peptide antibody; His3 1/13 antibody; Histatin-3 1/13); His3-(20-31)-peptide antibody; His3 20/31 antibody; His3-(1-12)-peptide antibody; His3 1/12 antibody; Histatin-3 1/12); His3-(20-30)-peptide antibody; His3 20/30 antibody; His3-(1-11)-peptide antibody; His3 1/11 antibody; Histatin-3 1/11); His3-(24-32)-peptide antibody; His3 24/32 antibody; His3-(5-13)-peptide antibody; His3 5/13 antibody; Histatin-3 5/13); His3-(24-31)-peptide antibody; His3 24/31 antibody; His3-(5-12)-peptide antibody; His3 5/12 antibody; Histatin-11 antibody; Histatin-3 5/12); His3-(24-30)-peptide antibody; His3 24/30 antibody; His3-(5-11)-peptide antibody; His3 5/11 antibody; Histatin-12 antibody; Histatin-3 5/11); His3-(25-32)-peptide antibody; His3 25/32 antibody; His3-(6-13)-peptide antibody; His3 6/13 antibody; Histatin-3 6/13); His3-(25-30)-peptide antibody; His3 25/30 antibody; His3-(6-11)-peptide antibody; His3 6/11 antibody; Histatin-3 6/11); His3-(26-32)-peptide antibody; His3 26/32 antibody; His3-(7-13)-peptide antibody; His3 7/13 antibody; Histatin-3 7/13); His3-(26-31)-peptide antibody; His3 26/31 antibody; His3-(7-12)-peptide antibody; His3 7/12 antibody; Histatin-3 7/12); His3-(26-30)-peptide antibody; His3 26/30 antibody; His3-(7-11)-peptide antibody; His3 7/11 antibody; Histatin-3 7/11); His3-(31-51)-peptide antibody; His3 31/51 antibody; His3-(12-32)-peptide antibody; His3 12/32 antibody; Histatin-3 12/32 antibody; Histatin-4); His3-(31-44)-peptide antibody; His3 31/44 antibody; His3-(12-25)-peptide antibody; His3 12/25 antibody; Histatin-3 12/25 antibody; Histatin-9); His3-(31-43)-peptide antibody; His3 31/43 antibody; His3-(12-24)-peptide antibody; His3 12/24 antibody; Histatin-3 12/24 antibody; Histatin-7); His3-(32-44)-peptide antibody; His3 32/44 antibody; His3-(13-25)-peptide antibody; His3 13/25 antibody; Histatin-10 antibody; Histatin-3 13/25); His3-(32-43)-peptide antibody; His3 32-43 antibody; His3-(13-24)-peptide antibody; His3 13/24 antibody; Histatin-3 13/24 antibody; Histatin-8); His3-(33-44)-peptide antibody; His3 33/44 antibody; His3-(14-25)-peptide antibody; His3 14/25 antibody; Histatin-3 14/25); His3-(33-43)-peptide antibody; His3 33/43 antibody; His3-(14-24)-peptide antibody; His3 14/24 antibody; Histatin-3 14/24); His3-(34-44)-peptide antibody; His3 34/44 antibody; His3-(15-25)-peptide antibody; His3 15/25 antibody; Histatin-3 15/25); His3-(34-43)-peptide antibody; His3 34/43 antibody; His3-(15-24)-peptide antibody; His3 15/24 antibody; Histatin-3 15/24); His3-(45-51)-peptide antibody; His3 45/51 antibody; His3-(26-32)-peptide antibody; His3 26/32 antibody; Histatin-3 26/32); His3-(47-51)-peptide antibody; His3 47/51 antibody; His3-(28-32)-peptide antibody; His3 28/32 antibody; Histatin-3 28/32); His3-(48-51)-peptide antibody; His3 48/51 antibody; His3-(29-32)-peptide antibody; His3 29/32 antibody; Histatin-3 29/32)] antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human Histatin-3 protein (20-34AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The HTN3 Antibody (Product code: CSB-PA010879NA01HU) is Non-conjugated. For HTN3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA010879NB01HU HTN3 Antibody, HRP conjugated ELISA
FITC CSB-PA010879NC01HU HTN3 Antibody, FITC conjugated
Biotin CSB-PA010879ND01HU HTN3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Antigen Affinity purified & Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
Gene References into Functions
  1. This aim of this study was to identify novel biomarkers using comparative global proteome analysis to improve the risk assessment for recurrent coronary events. Beta -defensin-128 and histatin-3 may be potential biomarkers whch may be used to improve risk the stratification for recurrent coronary events. PMID: 28627688
  2. the availability of Cu during exposure of Candida albicans to histatin-5 (Hist-5) modulates its antifungal activity. PMID: 28763199
  3. The aim of this study was to achieve a molecular understanding and a physico-chemical insight of the obtained small angle X-ray scattering and to gain information of the conformational changes of Histatin 5 due to altering salt content, charge distribution, and net charge. PMID: 26914439
  4. Histatin 5 Salivary Complexes PMID: 26544073
  5. Hst 5 may affect mitochondrial functions and cause oxidative stress; however, the ultimate cause of cell death is by volume dysregulation and ion imbalance triggered by osmotic stress. [Review] PMID: 24951439
  6. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
  7. analysis of histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins PMID: 22033918
  8. Histatin-5 is a likely transport molecule for toxic Ni(II) in human saliva.Its binding constant to nickel is five time higher than that of albumin. PMID: 21741339
  9. Hst 5 binding to beta-glucans on the cell wall of C. albicans is salt-sensitive. Uptake of Hst 5 shows dose-dependent translocation and intracellular accumulation precede vacuole expansion and propidium iodide uptake. PMID: 20487276
  10. Killing of Candida albicans requires cellular uptake and energy metabolism (Histatin 5) PMID: 11816973
  11. caused a loss of cell viability concomitant with a decrease in cellular volume as determined both by a classical candidacidal assay with exogenous Hst 5 and by using a genetically engineered C. albicans strain expressing Hst 5 (salivary histatin 5) PMID: 12183519
  12. study provides evidence for a novel function for yeast Ssa1/2 heat-shock proteins as cell envelope binding receptors for histatin 5 that mediate fungicidal activity PMID: 12761219
  13. results suggest that the genesis of histatin 3-related peptides, being under the principal action of trypsin-like activities, is probably not a random process but rather follows a sequential fragmentation pathway; cleavage sites are identified PMID: 15272024
  14. A 20-residue-derived histatin 5 peptide preserves anticandidal activity, binds DNA, and has nuclease activity in the presence of copper and zinc ions. PMID: 17176059
  15. Two cationic lysine residues at positions 2 and 10 in the P-113 peptide of Histatin 5 are important for transport into the cytosol of Candida albicans and that binding and transport are independent functional events. PMID: 17999963
  16. key steps of its lethal mechanism against parasites PMID: 18230684
  17. Gene polymorphism at codon 23 of the histatin 3 gene was not associated with periodontitis in the Japanese population. Rather it appeared to be associated with resistance to periodontitis. PMID: 19753800

Show More

Hide All

Subcellular Location
Secreted. Note=Secreted by serous acinar and demilune cells.
Protein Families
Histatin/statherin family
Database Links

HGNC: 5284

OMIM: 142702

KEGG: hsa:3347

STRING: 9606.ENSP00000432561

UniGene: Hs.654442

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*