HTRA2 Antibody

Datasheet
Code CSB-PA008885
Size US$167
Uniprot No. O43464
Protocols Immunohistochemistry (IHC) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from Human HtrA2 around the non-phosphorylation site of S212.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications IHC,ELISA;IHC:1/100-1/300.ELISA:1/40000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias HTRA2; OMI; PRSS25; Serine protease HTRA2; mitochondrial; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI
Immunogen Species Homo sapiens (Human)
Target Names HTRA2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Involvement in disease 3-methylglutaconic aciduria 8 (MGCA8); Parkinson disease 13 (PARK13)
Subcellular Location Mitochondrion intermembrane space, Mitochondrion membrane, Single-pass membrane protein
Protein Families Peptidase S1C family
Tissue Specificity Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
Database Links

HGNC: 14348

OMIM: 168600

KEGG: hsa:27429

STRING: 9606.ENSP00000258080

UniGene: Hs.469045

Pathway Apoptosis

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