HTRA2 Antibody

Datasheet
Code CSB-PA010902ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. O43464
Image
  • Western blot
    All lanes: HTRA2 antibody at 0.9µg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: U937 whole cell lysate
    Lane 3: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 49, 39, 47, 40 kDa
    Observed band size: 39 kDa

  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA010902ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010902ESR2HU at dilution of 1:100

Immunogen Recombinant Human Serine protease HTRA2, mitochondrial protein (334-458AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200
Relevance Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI), HTRA2, OMI PRSS25
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Neuroscience
Target Names HTRA2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Involvement in disease 3-methylglutaconic aciduria 8 (MGCA8); Parkinson disease 13 (PARK13)
Subcellular Location Mitochondrion intermembrane space, Mitochondrion membrane, Single-pass membrane protein
Protein Families Peptidase S1C family
Tissue Specificity Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
Database Links

HGNC: 14348

OMIM: 168600

KEGG: hsa:27429

STRING: 9606.ENSP00000258080

UniGene: Hs.469045

Pathway Apoptosis

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