HTRA2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA010902ED01HU
Size US$299
Uniprot No. O43464
Protocols ELISA Protocol
Immunogen Recombinant Human Serine protease HTRA2, mitochondrial protein (334-458AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI), HTRA2, OMI PRSS25
Immunogen Species Homo sapiens (Human)
Research Area Neuroscience
Target Names HTRA2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Involvement in disease 3-methylglutaconic aciduria 8 (MGCA8); Parkinson disease 13 (PARK13)
Subcellular Location Mitochondrion intermembrane space, Mitochondrion membrane, Single-pass membrane protein
Protein Families Peptidase S1C family
Tissue Specificity Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
Database Links

HGNC: 14348

OMIM: 168600

KEGG: hsa:27429

STRING: 9606.ENSP00000258080

UniGene: Hs.469045

Pathway Apoptosis

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