ICAM2 Antibody

Code CSB-PA006238
Size US$167
  • Western Blot analysis of MCF-7 cells using ICAM-2 Polyclonal Antibody
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Product Details

Uniprot No. P13598
Target Names ICAM2
Alternative Names ICAM2Intercellular adhesion molecule 2 antibody; ICAM-2 antibody; CD antigen CD102 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of Human ICAM-2.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Gene References into Functions
  1. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. PMID: 29671117
  2. ICAM2 induction by p53 has a key role in inhibiting cancer cell migration and invasion.ICAM2 acts at least in part through the suppression of the MEK-ERK signaling pathway. PMID: 27556181
  3. INDEED also identified some candidates previously reported to be relevant to HCC, such as intercellular adhesion molecule 2 (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were missed by both Differential expression and differential network analyses PMID: 27592383
  4. Both ICAM-2 and ICAM-1 levels in plasma were markedly increased in Ankylosing Spondylitis Chinese patients compared to controls. PMID: 26641849
  5. Soluble ICAM2 was higher in ADHD patients than in controls. PMID: 26377944
  6. Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells. PMID: 24704826
  7. with larger patient groups and preferably detailed histopathological and clinical evaluations, are needed to explain the severity of ICAM-1, ICAM-2, and ICAM-3 molecules in Barrett's esophagus PMID: 24474251
  8. ICAM-2 was significantly more pronounced in plasma cell mastitis than in nonpathologic breast tissue. However, no significant differences in ICAM-2 immunoreactivity were detected between ductal epithelium of PCM and non-PCM. PMID: 24457076
  9. Reduced glycosylation of ICAM-2 significantly attenuated, but did not abolish, its ability to suppress metastatic properties of neuroblastoma cells. PMID: 23714211
  10. These findings suggested that the downregulated miR-125b expression was associated with proliferation and radioresistance mechanisms, probably through ICAM2 signalling. PMID: 23591197
  11. Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
  12. Although ICAM-2 colocalizes with moesin and F-actin in microvilli of unstimulated endothelial cells, it is not involved in RhoA activation or cause stress fiber formation upon cross-linking. PMID: 12097408
  13. soluble DC-SIGN bound to gp120-Fc more than 100- and 50-fold better than ICAM-2-Fc and ICAM-3-Fc, respectively. Binding sites are described. PMID: 14970226
  14. The role of ICAM-2 has its recognition as potential therapeutic targets in human diseases. PMID: 15548573
  15. persistently elevated, serum levels of ICAM-2 throughout the various phases and types of Hemorrhagic fever with renal syndrome (HFRS) may be associated with the hyperfunctioning of the cellular immune response. PMID: 16987074
  16. pig and human ICAM-2 promoters exhibit many similarities PMID: 17059578
  17. The binding partner of DC-SIGN on endothelial cells is the glycan epitope Lewis(Y) (Le(Y)), expressed on ICAM-2. PMID: 18155766
  18. Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. PMID: 18768213
  19. ICAM-2 mediates suppression of metastatic phenotype and the interaction of ICAM-2/alpha-actinin/actin represents the first complete membrane-linker protein-actin linkage to impact tumor cell motility in vitro and metastatic potential in an in vivo model. PMID: 18978946

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily, ICAM family
Database Links

HGNC: 5345

OMIM: 146630

KEGG: hsa:3384

STRING: 9606.ENSP00000388666

UniGene: Hs.431460


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