ICAM4 Antibody

1. the effect of modulation of the cAMP-PKA-dependent pathway on ICAM-4 receptor activation PMID: 28076805
2. Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density. PMID: 26137540
3. Seven variant ICAM4 alleles were found, distinct from the wild-type ICAM4 allele (GenBank KF712272), known as LW*05 and encoding LW(a) . PMID: 24673173
4. Data from differentiating cultured erythroid precursor cells suggest that RhAG (Rh-associated glycoprotein) knockdown abolishes Rh blood group expression (ICAM4; RhoD [ras homolog family member D]; CD47 Rh-related antigen) in erythroid cells. PMID: 23417980
5. Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. PMID: 22147898
6. In a transgenic mouse model of sickle cell disease ICAM-4 is implicated in abnormal adhesiveness of erythrocytes to endothelium. PMID: 20015873
7. LWa allele occurs with incidence of 100% of donors in this study, while LWb allele has not been found in Chinese population. PMID: 18549656
8. ICAM-4 as the first red blood cells protein ligand of platelets that may have relevant physiological significance PMID: 12477717
9. binds to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins PMID: 12694184
10. 12 single amino-acid changes in ICAM4 affected the interaction of ICAM-4 with alpha(V) integrins PMID: 14551135
11. LW on sickle but not on normal erythrocytes undergoes increased PKA-dependent serine phosphorylation as a result of activation. The major counter receptor for LW was identified as the alphavbeta3 integrin on ECs PMID: 15308566
12. Different integrins bind to different but partly overlapping sites on ICAM4, and ICAM4 may accommodate multiple integrin receptors present on leukocytes, platelets and endothelial cells. PMID: 15355350
13. Review. LW antigen contributes to RBC adhesion, thrombosis, and (in sickle cell disease) vaso-occlusion. PMID: 16564726
14. We show that ICAM-4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM-4 demonstrated that both its domains contain binding sites for CD11c/CD18. PMID: 16985175
15. LW play potentially pathophysiological roles in sickle cell disease PMID: 17609430

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HGNC: 5347

OMIM: 111250

KEGG: hsa:3386

STRING: 9606.ENSP00000342114

UniGene: Hs.706750