IFT74 Antibody, Biotin conjugated

Code CSB-PA846657LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IFT74 Polyclonal antibody
Uniprot No.
Target Names
IFT74
Alternative Names
intraflagellar transport 74, Chlamydomonas, homolog of antibody; Capillary morphogenesis gene 1 protein antibody; Capillary morphogenesis protein 1 antibody; Ccdc2 antibody; CMG 1 antibody; CMG-1 antibody; Coiled-coil domain containing 2 antibody; Coiled-coil domain-containing protein 2 antibody; IFT74 antibody; IFT74_HUMAN antibody; intraflagellar transport 74 homolog (Chlamydomonas) antibody; intraflagellar transport 74 homolog antibody; Intraflagellar transport protein 74 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Intraflagellar transport protein 74 homolog protein (375-600AA )
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.
Gene References into Functions
  1. this study found that the two core intraflagellar transport proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74. PMID: 23990561
  2. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. PMID: 17383054
Involvement in disease
Bardet-Biedl syndrome 20 (BBS20)
Subcellular Location
Cell projection, cilium. Cytoplasmic vesicle. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis.
Protein Families
IFT74 family
Tissue Specificity
Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thym
Database Links

HGNC: 21424

OMIM: 608040

KEGG: hsa:80173

STRING: 9606.ENSP00000369402

UniGene: Hs.145402

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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