IGBP1 Antibody

1. Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c compared to expression levels of PP2Ac. PMID: 27169767
2. Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). PMID: 26876307
3. MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac in X-linked Opitz syndrome. PMID: 25207814
4. alpha4 is an important regulatory molecule of apoptosis and Bcl-xL phosphorylation induced by BCR crosslinking. PMID: 25876659
5. the alpha4 N-terminus binding to endogenous PP2Ac and PABP, and the C-terminus to EDD, is reported. PMID: 24145130
6. A potential important role of alpha4 in control of cell migration and/or invasion via the regulation of E-cadherin expression in bladder urothelial carcinoma. PMID: 24388773
7. The structure of alpha45 reveals two distinct surfaces, one that can interact with a negatively charged surface, which is present on PP2A, and one that interacts with the Bbox1 domain of MID1. PMID: 22194938
8. alpha4 is highly expressed in carcinogen-transformed human cells and primary human cancers. PMID: 21339737
9. both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation. PMID: 21454489
10. IGBP-1 is expressed universally in advanced lung adenocarcinomas, and its overexpression is significantly related to outcome. PMID: 21355954
11. Data show that in addition to PP2Ac, alpha4 interacts with EDD and PABP, suggesting its involvement in multiple steps in the mTOR pathway that leads to translation initiation and cell-cycle progression. PMID: 20544796
12. Alpha 4, a regulatory subunit of PP2-type phosphatases and a key component of the rapamycin-sensitive signaling pathway, has been indentified as a strong interactor of both MID1 and MID2. PMID: 11806752
13. alpha4 C-terminal deletion mutants at 222 (alpha4Delta222), 236 (alpha4Delta236) & 254 (alpha4Delta254) were expressed. alpha4Delta222 & alpha4Delta236 possess a higher content of alpha-helix, indicating that C-terminal region is less structured. PMID: 16517231
14. a new role for mTOR and alpha4/PP2Ac in the control of STAT1 nuclear content, and the expression of interferon-gamma-sensitive genes involved in immunity and apoptosis. PMID: 19553685

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HGNC: 5461

OMIM: 300139

KEGG: hsa:3476

STRING: 9606.ENSP00000348784

UniGene: Hs.496267