IL12A Antibody

Datasheet
Code CSB-PA877335
Size US$299
Uniprot No. P29459
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA877335(IL12A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA877335(IL12A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human IL12A
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,IHC;ELISA:1:1000-1:2000,IHC:1:10-1:50
Relevance This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias interleukin 12A
Immunogen Species Homo sapiens (Human)
Target Names IL12A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Subcellular Location Secreted
Protein Families IL-6 superfamily
Database Links

HGNC: 5969

OMIM: 161560

KEGG: hsa:3592

STRING: 9606.ENSP00000303231

UniGene: Hs.673

Pathway Jak-STAT signaling pathway
Th1 and Th2 cell differentiation
Toll-like receptor signaling pathway

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