INF2 Antibody

Code CSB-PA637740LA01HU
Size US$166
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  • IHC image of CSB-PA637740LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA637740LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) INF2 Polyclonal antibody
Uniprot No.
Target Names
INF2
Alternative Names
C14orf151 antibody; C14orf173 antibody; CMTDIE antibody; DKFZp762A0214 antibody; FLJ22056 antibody; FSGS5 antibody; HBEAG binding protein 2 binding protein C antibody; HBEBP2 binding protein C antibody; HBEBP2-binding protein C antibody; INF 2 antibody; inf2 antibody; INF2_HUMAN antibody; Inverted formin 2 antibody; Inverted formin FH2 and WH2 domain containing antibody; Inverted formin-2 antibody; MGC13251 antibody; pp9484 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Inverted formin-2 protein (926-1047AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The INF2 Antibody (Product code: CSB-PA637740LA01HU) is Non-conjugated. For INF2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA637740LB01HU INF2 Antibody, HRP conjugated ELISA
FITC CSB-PA637740LC01HU INF2 Antibody, FITC conjugated
Biotin CSB-PA637740LD01HU INF2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Severs actin filaments and accelerates their polymerization and depolymerization.
Gene References into Functions
  1. INF2-mediated actin polymerization on the endoplasmic reticulum stimulates mitochondrial division by two independent mechanisms: (1) mitochondrial calcium uptake, leading to inner mitochondrial membrane constriction; and (2) Drp1 oligomerization, leading to outer mitochondrial membrane constriction. PMID: 29142021
  2. Studies indicate that INF2, a formin, that is mutated in hereditary renal and neurodegenerative disorders. PMID: 29947928
  3. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
  4. hese findings reveal novel molecular events underlying the regulation of INF2 function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer. PMID: 28448495
  5. All individuals with INF2 mutations presenting with a thrombotic microangiopathy also had atypical hemolytic uremic syndrome risk haplotypes, potentially accounting for the genetic pleiotropy PMID: 27974406
  6. Propose that examination of INF2 expression may help to differentiate minimal change disease from focal segmental glomerulosclerosis and evaluate the clinical severity of steroid resistance nephrotic syndrome in children. PMID: 26383224
  7. FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes. PMID: 26621033
  8. Report novel mutations in the inverted formin 2 gene of Chinese families contributing to focal segmental glomerulosclerosis. PMID: 26039629
  9. Assembly and turnover of short actin filaments by the formin INF2 and profilin. PMID: 26124273
  10. INF2 mutations are associated with focal segmental glomerulosclerosis. PMID: 25165188
  11. this study identifed three novel mutations of INF likely efect hereditary neuropathy with glomerulopathy. PMID: 24174593
  12. actin monomer binding to the DAD of INF2 competes with the DID/DAD interaction, thereby activating actin polymerization PMID: 23921379
  13. INF2 mutation was detected both father and his son PMID: 23847988
  14. This study showed that INF2 mutations in Charcot-Marie-Tooth disease complicated with focal segmental glomerulosclerosis. PMID: 23521651
  15. In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling. PMID: 23620398
  16. INF2 mutations were found in 2 of 281 individuals with sporadicfocal and segmental glomerulosclerosis PMID: 23014460
  17. Our study confirms the link between INF2 mutations and Charcot-Marie-Tooth-associated glomerulopathy and widens the spectrum of pathogenic mutations. PMID: 22961558
  18. A novel mutation, outside of the candidate region for diagnosis, in the inverted formin 2 gene can cause focal segmental glomerulosclerosis. PMID: 22971997
  19. Formation of stabilized, detyrosinated microtubules required the formin INF2. PMID: 22986496
  20. study found actin polymerization through ER-localized INF2 was required for efficient mitochondrial fission; INF2-induced actin filaments may drive initial mitochondrial constriction, which allows Drp1-driven secondary constriction PMID: 23349293
  21. Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing. PMID: 22879592
  22. Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture. PMID: 21998196
  23. INF2 mutations were responsible for 16% of all cases of autosomal dominant focal and segmental glomerulosclerosis, with these mutations clustered in exon 4. PMID: 21866090
  24. Actin monomers inhibit microtubule binding/bundling by INF2 PMID: 21998204
  25. INF2 mutations appear to cause many cases of FSGS-associated Charcot-Marie-Tooth neuropathy, showing that INF2 is involved in a disease affecting both the kidney glomerulus and the peripheral nervous system. PMID: 22187985
  26. The effects of disease-causing INF2 mutations suggest an important role for this protein and its interaction with other formins in modulating glomerular podocyte phenotype and function. PMID: 21278336
  27. In conclusion, we described an additional familial case of the autosomal dominant form of focalsegmental glomerulosclerosis associated with INF2 mutations. PMID: 20803156
  28. Six of the seven distinct altered residues localized to an INF2 region that corresponded to a subdomain of the mDia1 diaphanous inhibitory domain reported to co-immunoprecipitate with IQ motif-containing GTPase-activating protein 1 PMID: 21258034
  29. Study identified nine independent nonconservative missense mutations in INF2, which encodes a member of the formin family of actin-regulating proteins. PMID: 20023659

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Involvement in disease
Focal segmental glomerulosclerosis 5 (FSGS5); Charcot-Marie-Tooth disease, dominant, intermediate type, E (CMTDIE)
Subcellular Location
Cytoplasm, perinuclear region.
Protein Families
Formin homology family
Tissue Specificity
Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells.
Database Links

HGNC: 23791

OMIM: 610982

KEGG: hsa:64423

STRING: 9606.ENSP00000376410

UniGene: Hs.24956

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