ING2 Antibody

1. The ING1L gene may be involved in basal cell carcinogenesis. PMID: 15005689
2. P33ING2 cooperates with p53 to regulate apoptosis via activation of both the mitochondrial/intrinsic and death-receptor/extrinsic apoptotic pathways. PMID: 15748897
3. ING2 can act as a cofactor of p300 for p53 acetylation and thereby plays a positive regulatory role during p53-mediated replicative senescence. PMID: 16024799
4. The expression of ING2 was down-regulated in 6 of 7 lung cancer cell lines that had a p53 mutation. PMID: 16465410
5. Observations suggest that p33ING2 is required for the initial DNA damage sensing and chromatin remodeling in the nucleotide excision repair process. PMID: 16488987
6. The data showed that nuclear ING2 expression was significantly reduced in radial growth phase (RGP), vertical growth phase (VGP), and metastatic melanomas compared with dysplastic nevi (P < 0.05). PMID: 16755297
7. Deletion of leucine zipper-like (LZL)abrogated the association between ING2 and p53, suggesting that ING2 modulates p53-dependent chromatin remodeling, apoptosis and DNA repair. PMID: 16782091
8. molecular modeling and docking of the 5-methylenephosphonate or 5-phosphothionate analogues to the C-terminus PtdInsP-binding region of ING2 revealed a number of complementary surface and electrostatic contacts between the lipids and ING2 PMID: 17469822
9. p33ING2/ING1L is a DNA damage-inducible gene that negatively regulates cell proliferation through activation of p53 by enhancing its acetylation. PMID: 11481424
10. Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. PMID: 27305909
11. ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis. PMID: 26717876
12. Results suggest that ING2 acts as a tumor suppressor in osteosarcoma. PMID: 25190103
13. It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor. PMID: 25613071
14. Decreased expression of ING2 gene is associated with non-small cell lung cancer. PMID: 24712846
15. It was concluded that ING2 not only plays an essential role in the growth and invasion of MGC-803 cells but also represents a potential approach to chemosensitization therapy in human gastric cancer. PMID: 23864195
16. findings support a model in which PtdIns(5)P functions as a sub-nuclear trafficking factor that stabilizes ING2 at discrete genomic sites PMID: 23823870
17. Study establishes ING2 as a novel regulator of spermatogenesis functioning, and provides an animal model to study idiopathic and iatrogenic infertility in men. PMID: 21124965
18. Data show that inhibition of ING2 expression accelerates progression of cells from G(1) to S-phase, and is accompanied by a decrease of p21 expression, and that regulation of p21 by ING2 is independent of p53. PMID: 20890119
19. expression is downregulated in non-small cell lung carcinoma PMID: 19962781
20. sumoylation of ING2 enhances its binding to the Sin3A/HDAC complex and is required to regulate gene transcriptions PMID: 20676127
21. Decreased expression of ING2 gene is associated with hepatocellular carcinoma PMID: 18160212
22. ING2 collaborates with SnoN to mediate TGF-beta-induced Smad-dependent transcription and cellular responses PMID: 18334480
23. p53-mediated mir34a, mir34b, and mir34c up-regulation and ING2 down-regulation may be involved in the senescence pathway. PMID: 18451145
24. ING2 C-terminus recruits histone methyltransferase activity, which correlates with silencing function PMID: 18513492
25. ING2a knockdown suppressed cell growth only in the presence of p53, ING2b knockdown had no effect on cell growth, and knockdown of both induced cell cycle arrest and apoptosis independently of p53. PMID: 18951897
26. ING2 loss of heterozygosity is associated with advanced staging in head and neck squamous cell carcinoma and determines survival rate. PMID: 18998165
27. ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. PMID: 19437536
28. found that ING2 interacts with proliferating cell nuclear antigen and regulates its amount to the chromatin fraction, allowing normal replication progression and normal cell proliferation. PMID: 19730436

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HGNC: 6063

OMIM: 604215

KEGG: hsa:3622

STRING: 9606.ENSP00000307183

UniGene: Hs.107153