INPP5E Antibody, HRP conjugated

Datasheet
Code CSB-PA873641LB01HU
Size US$299
Uniprot No. Q9NRR6
Immunogen Recombinant Human 72 kDa inositol polyphosphate 5-phosphatase protein (1-133AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias 72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV), INPP5E
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names INPP5E
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
Involvement in disease Joubert syndrome 1 (JBTS1); Mental retardation, truncal obesity, retinal dystrophy, and micropenis (MORMS)
Subcellular Location Cytoplasm, cytoskeleton, cilium axoneme, Golgi apparatus, Golgi stack membrane, Peripheral membrane protein, Cytoplasmic side, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, ruffle, Cytoplasm
Protein Families Inositol 1,4,5-trisphosphate 5-phosphatase type IV family
Tissue Specificity Detected in brain, heart, pancreas, testis and spleen.
Database Links

HGNC: 21474

OMIM: 213300

KEGG: hsa:56623

STRING: 9606.ENSP00000360777

UniGene: Hs.120998

Pathway Phosphatidylinositol signaling system

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