INPP5K Antibody

Code CSB-PA866277ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA866277ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) INPP5K Polyclonal antibody
Uniprot No.
Target Names
INPP5K
Alternative Names
43 kDa form skeletal muscle and kidney enriched inositol phosphatase antibody; Inositol polyphosphate 5-phosphatase K antibody; INP5K_HUMAN antibody; INPP5K antibody; muscle and kidney-enriched inositol phosphatase antibody; PPS antibody; skeletal muscle and kidney enriched inositol phosphatase antibody; Skeletal muscle and kidney-enriched inositol phosphatase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Inositol polyphosphate 5-phosphatase K protein (149-448AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.
Gene References into Functions
  1. the distribution of genotype frequency exhibited no significant differences between the Parkinson's disease and control groups (P > 0.025) in INPP5K rs1109303 (P = 0.048, OR = 0.806, 95%CI = 0.650 - 0.998). PMID: 29607885
  2. In individuals exhibiting congenital muscular dystrophy, early-onset cataracts, and mild intellectual disability but normal cranial magnetic resonance imaging, we identified bi-allelic mutations in INPP5K, encoding inositol polyphosphate-5-phosphatase K. PMID: 28190456
  3. Mutations in INPP5K cause a congenital muscular dystrophy syndrome with short stature, cataracts, and intellectual disability. PMID: 28190459
  4. These findings suggest a model by which GRP78 regulates intracellular localization of SKIP and how SKIP binds to Pak1 on insulin stimulation. PMID: 26940976
  5. Study reveals that SKIP is a significant regulator of glioblastoma cell migration and that increased expression of SKIP may confer a survival advantage. PMID: 25241900
  6. SKIP controls the IGF-II-PI 3-kinase-Akt-mTOR auto-regulation loop during myogenesis. PMID: 22815484
  7. Specific suppression of insulin signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1. PMID: 22751929
  8. identification of novel domain that mediates membrane ruffle localization PMID: 12536145
  9. The authors report that HBV core protein interacts with a cellular SKIP (skeletal muscle and kidney enriched inositol phosphatase) protein, an endoplasmic reticulum-located phosphoinositide 5-phosphatase, both in vivo and in vitro. PMID: 18774950

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Involvement in disease
Muscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID)
Subcellular Location
Endoplasmic reticulum. Cytoplasm.
Protein Families
Inositol 1,4,5-trisphosphate 5-phosphatase type II family
Tissue Specificity
Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
Database Links

HGNC: 33882

OMIM: 607875

KEGG: hsa:51763

STRING: 9606.ENSP00000413937

UniGene: Hs.632238

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