INSC Antibody

Datasheet

Code	CSB-PA011744GA01HU
Size	$600
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Target Background

Product Details

Uniprot No.

Q1MX18

Target Names

INSC

Alternative Names

Insc antibody; INSC_HUMAN antibody; Inscuteable homolog (Drosophila) antibody; Protein inscuteable homolog antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human INSC

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles.

Form

Liquid

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.

Gene References into Functions

In mammary stem cells, the asymmetric domain of Insc bound to LGN:Galphai(GDP) suffices to drive asymmetric fate, and reverts aberrant symmetric divisions induced by p53 loss. PMID: 29523789
Studies indicate that the Inscuteable (Insc)and NuMA are mutually exclusive interactors of LGN. PMID: 22977735
mInsc-LGN interaction is vital for stabilization of LGN and for intracellular localization of mInsc. PMID: 22074847
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
These data present AGS3, G-proteins, and mInsc as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies. PMID: 20065032
cloning of two distinct cDNAs from Insc gene, which is differentially expressed from alternative first exons;Insc proteins bind to the Pins homologues LGN and AGS3, and also to Par3 and Par3beta PMID: 16458856

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Subcellular Location

Cytoplasm. Cytoplasm, cell cortex.

Tissue Specificity

Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas.

Database Links

HGNC: 33116

OMIM: 610668

KEGG: hsa:387755

STRING: 9606.ENSP00000368872

UniGene: Hs.591997

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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