IPPK Antibody

Datasheet

Code	CSB-PA050062
Size	US$100
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Product Details
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Target Background

Product Details

Uniprot No.

Q9H8X2

Target Names

IPPK

Alternative Names

3 antibody; 4 antibody; 5 antibody; 6)P5 2-kinase antibody; 6-pentakisphosphate 2-kinase antibody; bA476B13.1 (novel protein) antibody; bA476B13.1 antibody; C9orf12 antibody; inositol 1,3,4,5,6 pentakisphosphate 2 kinase antibody; Inositol pentakisphosphate 2 kinase antibody; Inositol-1 antibody; Inositol-pentakisphosphate 2-kinase antibody; Ins antibody; Ins(1 antibody; Ins(1,3,4,5,6)P5 2 kinase antibody; InsP5 2 kinase antibody; InsP5 2-kinase antibody; INSP5K2 antibody; IP5K antibody; IPK1 antibody; IPK1 homolog antibody; IPPK antibody; IPPK_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the N-terminal region of Human InsP5 2-kinase.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.

Gene References into Functions

These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
IP6 synthase, Ins(1,3,4,5,6)P5 2-kinase (IPPK/IP5K) binds to cullins. Depleting IP5K increases the percentage of neddylated, active Cul1 and Cul4A, and decreases levels of the Cul1/4A substrates p27 and p21. PMID: 26976604
IPK1 substrate selection is linked to the ability of each potential substrate to stabilize IPK1. PMID: 24165122
identified a genomic DNA sequence on chromosome 9 that encodes inositol 1,3,4,5,6-pentakisphosphate 2-kinase; characterization of the enzyme PMID: 12084730

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

IPK1 type 2 family

Tissue Specificity

Ubiquitously expressed, with high expression in heart, brain, testis and placenta.

Database Links

HGNC: 14645

KEGG: hsa:64768

STRING: 9606.ENSP00000287996

UniGene: Hs.459896

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Phosphatidylinositol signaling system

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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