IQGAP2 Antibody

1. IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability PMID: 29073199
2. The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered. PMID: 27524202
3. The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2. PMID: 27163930
4. IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population. PMID: 26187738
5. Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/b-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease. PMID: 26549344
6. we identified IQGAP2 as a human and zebrafish podocyte gene product that is downregulated in microarray data sets from kidney biopsies of human patients with focal segmental glomerulosclerosis and minimal change nephrotic syndrome. PMID: 26154927
7. Data show that IQ motif-containing GTPase-activating protein 2 (IQGAP2) expression is altered in colitis. PMID: 26047140
8. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review) PMID: 25722290
9. Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis. PMID: 25229330
10. Low IQGAP2 expression was associated with hepatocellular carcinoma. PMID: 24998570
11. The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin in the absence of calcium. PMID: 21299499
12. observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer PMID: 22406297
13. increased IQGAP1 and/or decreased IQGAP2 contribute to the pathogenesis of human HCC. PMID: 20977743
14. The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2). PMID: 20068591
15. The gene for the putative rac1/cdc42 effector protein IQGAP2 was found in the PAR gene cluster at 5q13, flanked by PAR1 & encompassing PAR3. It functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. PMID: 12515716
16. silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development. PMID: 17957782

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HGNC: 6111

OMIM: 605401

KEGG: hsa:10788

STRING: 9606.ENSP00000274364

UniGene: Hs.291030