IRX1 Antibody

1. Multiple evidences suggested that PRMT5 repressed transcription of tumor suppressor IRX1 via recruitment of DNMT3A on promoter. PMID: 29802960
2. A total of three nonsynonymous mutations (p.Gln240Glu, p.Ser298Asn and p.Ala381Glu) of the IRX1 gene were verified in 215 nonsyndromic congenital heart disease patients. PMID: 28358424
3. this is the first genome-wide association study of Rheumatoid Factor positivity in Rheumatoid Arthritis. Variation at the IRX1 locus on chromosome 5p15.3 is associated with the presence of Rheumatoid Factor. Our findings indicate that IRX1 and HLA-DRB1 are the strongest genetic factors for Rheumatoid Factor production in Rheumatoid Arthritis. PMID: 26815016
4. In osteosarcoma cells and lines, IRX1 overexpression was associated with hypomethylation of its own promoter. Experimental modulation in cell lines altered migration, invasion, and resistance to anoikis in vitro, and influenced lung metastasis in mice. PMID: 25822025
5. Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 genes may play an important role in a pathogenic effect of TGF-beta on RASFs. PMID: 23456299
6. Helicobacter pylori infection contributes to IRX1 promoter methylation in gastric mucosa. PMID: 21649733
7. enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion. PMID: 21602894
8. IRX1 could potentially serve as a biomarker for gastric cancer. PMID: 20440264
9. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
10. Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma. PMID: 20440264
11. Frequent methylation of IRX1 gene is associated with head and neck squamous cell carcinoma PMID: 18559491

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HGNC: 14358

OMIM: 606197

KEGG: hsa:79192

STRING: 9606.ENSP00000305244

UniGene: Hs.424156