IRX2 Antibody

Code CSB-PA003070
Size US$100
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  • Western Blot analysis of HepG2 cells using IRX2 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
IRX2
Alternative Names
Homeodomain protein IRXA2 antibody; Iroquois homeobox 2 antibody; Iroquois homeobox protein 2 antibody; Iroquois-class homeodomain protein irx-2 antibody; IRX 2 antibody; irx2 antibody; IRX2_HUMAN antibody; IrxA2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human IRX2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. IRX2 transcription factor might represent a novel metastasis associated protein that acts as a negative regulator of cellular motility and as a repressor of chemokine expression and loss of IRX2 expression could therefore contribute to early hematogenous dissemination of breast cancer by sustaining chemokine secretion and enabling mobilization of tumor cells. PMID: 26560478
  2. IRX2 modulates the expression levels of MMP2 and VEGF in an AKTdependent manner. PMID: 26062523
  3. The mechanism by which IRX2 promoted cell proliferation and invasion by activating AKT and MMP9 was detected. PMID: 24806332
  4. Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2. PMID: 22210879
  5. IRX2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease. PMID: 16752383

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Subcellular Location
Nucleus.
Protein Families
TALE/IRO homeobox family
Database Links

HGNC: 14359

OMIM: 606198

KEGG: hsa:153572

STRING: 9606.ENSP00000307006

UniGene: Hs.282089

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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