ITGAE Antibody

Code CSB-PA939663
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA939663(ITGAE Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA939663(ITGAE Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: LoVo cells, Primary antibody: CSB-PA939663(ITGAE Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
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Product Details

Uniprot No. P38570
Target Names ITGAE
Alternative Names A530055J10 antibody; alpha-E1 antibody; alpha-M290 antibody; aM290 antibody; Antigen CD103 antibody; CD 103 antibody; CD103 antibody; CD103 antigen antibody; HML 1 antigen antibody; HML-1 antigen antibody; HML1 antigen antibody; Human mucosal lymphocyte antigen 1 antibody; Human mucosal lymphocyte antigen 1, alpha subunit antibody; Huminae antibody; Integrin alpha E antibody; Integrin alpha E heavy chain antibody; Integrin alpha E light chain antibody; Integrin alpha E, epithelial-associated antibody; Integrin alpha E1 antibody; Integrin alpha IEL antibody; Integrin alpha M290 antibody; Integrin alpha-E heavy chain antibody; Integrin alpha-IEL antibody; Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide) antibody; Integrin, alpha E antibody; ITAE_HUMAN antibody; Itgae antibody; MGC141996 antibody; MGC183601 antibody; Mucosal lymphocyte 1 antigen antibody; Mucosal lymphocyte antigen 1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Fusion protein of Human ITGAE
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
Gene References into Functions
  1. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. PMID: 30006565
  2. Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cell migratory behavior and effector functions. PMID: 29021139
  3. The CD103+CD4+/CD4+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4+/CD8+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis. PMID: 27230039
  4. CD103 expression in human dendritic cells is regulated differentially by retinoic acid and Toll-like receptor ligands. PMID: 28087652
  5. detected CD103 tumor cells in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma PMID: 26813744
  6. Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients. PMID: 26522261
  7. PD-1(+)CD103(+) CD8 TIL might regain functional antitumor activity, an effect that potentially could be augmented by immune modulation. PMID: 25957117
  8. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with refractory celiac disease. PMID: 25637255
  9. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103 PMID: 25584868
  10. Report CD103 expression occurs most frequently in gastrointestinal T-cell lymphomas. PMID: 25025448
  11. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. PMID: 24190978
  12. Using a human CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are two critical regulators of this process. PMID: 24477908
  13. Memory CD103+ CD8 T cells that persist within the brain after an acute infection with vesicular stomatitis virus are bona fide tissue resident memory cells. PMID: 22922816
  14. Lymphoid tissue (LT)-resident CD8alpha-positive dendritic cells (DCs) and non(LT)-derived CD103-positive DCs express transgenic XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. PMID: 21948982
  15. These findings support the usefulness of CD123 and CD103 to aid in the differential diagnosis of B-cell lymphoproliferative disorders PMID: 21917686
  16. Studies indicate that the mechanisms that regulate the retention of tissue-resident memory T cells include TGF-beta-mediated induction of CD103 and downregulation of CCR7. PMID: 21739671
  17. results show that binding of the human alphaE I domain to oral and skin keratinocytes is independent of E-cadherin PMID: 20875079
  18. has a role in mucosal immunity and graft rejection PMID: 12370249
  19. Involvement of the adhesive ligand pair CD103-E-cadherin in human thymocyte cell proliferation PMID: 12414996
  20. Differential up-regulation of CD103 expression on lamina propria lymphocytes in Crohn's disease may indicate differential humoral or cellular regulation in inducing CD103 molecules on lymphocytes in patients with this disease PMID: 14532999
  21. CD103 promotes destruction of renal allografts by CD8 T cells PMID: 15196058
  22. Integrin/activation marker CD103 (alphaEbeta7) is expressed on Epstein-Barr virus-specific tonsil-resident (but not peripheral blood mononuclear leukocyte-derived) cytotoxic T lymphocytes. PMID: 16177076
  23. CD103 expression on dendritic cells influences the balance between effector and regulatory T cell activity in the intestine. PMID: 16216886
  24. human alloantigen-induced CD103+ CD8+ T cells possess functional features of regulatory T cells PMID: 16920912
  25. CD8+/CD103+ tumor-reactive T lymphocytes infiltrating epithelial tumors most likely play a major role in antitumor cytotoxic response through alphaEbeta7-E-cadherin interactions. PMID: 17325197
  26. An investigation to evaluate the diagnostic value of relative number of CD103 expressing CD4(+) T-lymphocytes in the BAL fluid of patients with a variety of interstitial lung diseases, including pulmonary sarcoidosis, is reported. PMID: 18182176
  27. integrin alpha(E)(CD103)beta(7) is not only involved in epithelial retention, but also in shaping and proper intraepithelial morphogenesis of some leukocytes. PMID: 18492951
  28. Phenotypic analysis of peripheral blood and decidual CD8+ T cells showed the presence of activated CD8+ T cells as well as a population of CD8+CD103+ T cells in decidual tissue PMID: 19150377
  29. A higher proportion of CD103+CD4+ T cells and ITGAE -1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis. PMID: 19604725

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Integrin alpha chain family
Tissue Specificity Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
Database Links

HGNC: 6147

OMIM: 604682

KEGG: hsa:3682

STRING: 9606.ENSP00000263087

UniGene: Hs.513867

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