IVNS1ABP Antibody, HRP conjugated

Datasheet

Code	CSB-PA896937LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) IVNS1ABP Polyclonal antibody

Uniprot No.

Q9Y6Y0

Target Names

IVNS1ABP

Alternative Names

IVNS1ABP antibody; ARA3 antibody; FLARA3 antibody; KIAA0850 antibody; KLHL39 antibody; NS1 antibody; NS1BP antibody; HSPC068 antibody; Influenza virus NS1A-binding protein antibody; NS1-BP antibody; NS1-binding protein antibody; Aryl hydrocarbon receptor-associated protein 3 antibody; Kelch-like protein 39 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Influenza virus NS1A-binding protein (401-642AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.

Gene References into Functions

Data show that heterogeneous nuclear ribonucleoprotein K (hnRNP K) and influenza virus NS1A binding protein (NS1-BP) regulate host splicing events and that viral infection causes mis-splicing of some of these transcripts. PMID: 29921878
Our study identifies KLHL39 as a negative regulator of Cul3-KLHL20 ubiquitin ligase and reveals a role of KLHL39-mediated PML and DAPK stabilization in colon cancer metastasis. PMID: 25619834
NS1-BP-hnRNPK complex is a key mediator of influenza A virus gene expression. PMID: 23825951
This study provided evidence that miRNA-548an is involved in the regulation of NS1ABP. PMID: 24210102
These findings further support the distinct roles of alpha-enolase and its MBP-1 variant in maintaining cell homeostasis. Moreover, these data suggest a novel function for NS1-BP in the control of cell proliferation. PMID: 17996313

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Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm.

Database Links

HGNC: 16951

OMIM: 609209

KEGG: hsa:10625

STRING: 9606.ENSP00000356468

UniGene: Hs.497183

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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