JADE1 Antibody

1. identification of SNPs within the IQCJ, NXPH1, PHF17 and MYB genes partly explaining the large interindividual variability observed in plasma triglyceride levels in response to an n-3 fatty acid supplementation PMID: 27160456
2. A genome-wide association study (GWAS) identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB. PMID: 28134766
3. JADE1 expression has a role in colon cancers, renal carcinomas, and in acute kidney injuries and regeneration. (Review) PMID: 27155521
4. Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis. PMID: 26919559
5. JADE1S protein localized to centrosomes in interphase and mitotic cells, and to the midbody during cytokinesis. PMID: 26151225
6. Casein kinase 1 alpha specifically phosphorylates Jade-1 at an unprimed SLS phosphorylation site. PMID: 25100726
7. Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 shuttling during organ regeneration. PMID: 24739512
8. lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis. PMID: 24097061
9. Reduced Jade-1 expression is associated with clear-cell renal cell carcinomas. PMID: 23824745
10. The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling. PMID: 22654112
11. RCC with a low expression of Jade-1 is associated with a poor outcome and decreased survival PMID: 22516360
12. Jade-1 protein is a novel candidate regulatory factor in Von Hippel Lindau-mediated renal tumor suppression PMID: 12169691
13. Jade-1 is a novel candidate transcriptional co-activator associated with HAT activity and may play a key role in the pathogenesis of renal cancer and von Hippel-Lindau disease PMID: 15502158
14. Jade-1 may suppress renal cancer cell growth in part by increasing apoptosis. PMID: 16046545
15. Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation PMID: 18684714
16. The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1. PMID: 18806787

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HGNC: 30027

OMIM: 610514

KEGG: hsa:79960

STRING: 9606.ENSP00000226319

UniGene: Hs.12420