KATNA1 Antibody

Datasheet

Code	CSB-PA011990GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O75449

Target Names

KATNA1

Alternative Names

Katanin p60 ATPase containing subunit A1 antibody; Katanin p60 ATPase-containing subunit A1 antibody; Katanin p60 subunit A1 antibody; KATNA1 antibody; KTNA1_HUMAN antibody; OTTHUMP00000017392 antibody; OTTHUMP00000042860 antibody; p60 katanin antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human KATNA1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Gene References into Functions

CAMSAP3 precisely coordinates with dynein and katanin to regulate the microtubule detachment process. PMID: 28386021
Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails PMID: 26682813
analysis of spastin's microtubule-binding properties and comparison with katanin PMID: 23272056
Data propose a model in which spatial rearrangement of the p60 katanin N-terminal domain relative to the C-terminal AAA domain may be important for productive ATP hydrolysis towards MT-severing. PMID: 22325007
Katanin p60 was aberrantly expressed during prostate cancer progression. The elevated katanin p60 expression may contribute to cancer cell metastasis via a stimulatory effect on cell motility. PMID: 21681775
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization PMID: 20339000

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Subcellular Location

Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle.

Protein Families

AAA ATPase family, Katanin p60 subunit A1 subfamily

Database Links

HGNC: 6216

OMIM: 606696

KEGG: hsa:11104

STRING: 9606.ENSP00000335106

UniGene: Hs.450175

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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