KCNE4 Antibody

1. The KCNE1 (rs1805127) appears to an independent risk factor for AF in the Uygur population. And the KCNE4 (rs12621643) was an independent risk factor for AF among both Uygurs and Hans. PMID: 28981946
2. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction. PMID: 27802162
3. the association of the KCNE4 gene variability with allergic rhinitis PMID: 23866632
4. KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1. PMID: 21118809
5. MiRP3 modulates Kv4.2 current activation, inactivation and recovery from inactivation. MiRP3 shifts the half-maximal voltage for activation and slows time to peak ~ 100%. PMID: 20498229
6. KCNE4 E145D polymorphism may be related to atrial fibrillation. PMID: 16563243
7. KCNE4 (potassium voltage-gated channel subfamily E member 4), but not KCNE2, functions as an inhibitory Kv1.3 partner in leukocytes. PMID: 19773357
8. expressed strongly in heart, skeletal muscle, and kidney, less in placenta, lung, and liver, and weakly in brain and blood cells. Electrophysiological study showed that KCNE4 modulates the activation of the KCNQ1 channel. PMID: 12670483
9. KCNE4 beta-subunit has a drastic inhibitory effect on currents generated by Kv1.1 and Kv1.3 potassium channels PMID: 12944270
10. Based upon previous studies and the present results, it is concluded that both hKCNE4 and mKCNE4 have a drastic inhibitory impact on both hKCNQ1 and mKCNQ1 currents. PMID: 15707997
11. The non-synonymous single nucleotide polymorphism E145D may be associated with the atrial fibrillation phenotype. PMID: 17016049
12. KCNE4 directly associates with KCNQ1, and can co-associate together with KCNE1 in the same KCNQ1 complex to form a 'triple subunit' complex (KCNE1-KCNQ1-KCNE4). PMID: 18279388
13. MiRP3 (encoded by the KCNE4 gene) plays a role in modulation of BK-dependent urinary potassium excretion. PMID: 18463315
14. Specific KCNE4 domains responsible for the inhibitory effects on heterologously expressed KCNQ1 were identified. The KCNE4 C-terminus is critical for KCNQ1 modulation and physically interacts with KCNQ1. PMID: 19029186

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HGNC: 6244

OMIM: 607775

KEGG: hsa:23704

STRING: 9606.ENSP00000281830

UniGene: Hs.348522