KCNH3 Antibody

Code CSB-PA008367
Size US$100
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Product Details

Uniprot No.
Target Names
KCNH3
Alternative Names
KCNH3 antibody; KIAA1282Potassium voltage-gated channel subfamily H member 3 antibody; Brain-specific eag-like channel 1 antibody; BEC1 antibody; Ether-a-go-go-like potassium channel 2 antibody; ELK channel 2 antibody; ELK2 antibody; Voltage-gated potassium channel subunit Kv12.2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human KCNH3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Gene References into Functions
  1. report on the binding of HIV-1 gp120 to the cytoplasmic C-terminus of the voltage-gated potassium channel BEC1, an interaction that can result in the repression of BEC's activity and the inhibition of HIV-1 particle-release PMID: 20638388
  2. BEC1 is negatively involved in cognitive functions with no abnormal behaviors such as spontaneous seizures or motor dysfunction. PMID: 19923296
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv12.2/KCNH3 sub-subfamily
Tissue Specificity
Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.
Database Links

HGNC: 6252

OMIM: 604527

KEGG: hsa:23416

STRING: 9606.ENSP00000257981

UniGene: Hs.64064

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