KCNH5 Antibody

1. EAG2 potassium channel has an evolutionarily conserved function for promoting brain tumor growth. PMID: 26258683
2. The observed Ca(2+)-induced proteolytic cleavage of EAG2 channel may act as an adaptive response under physiological and/or pathological conditions. PMID: 25542181
3. Study propose that hypomethylation of the placental-specific KCNH5 promoter is frequently associated with KCNH5 expression in melanoma cells. PMID: 24759919
4. Our results demonstrate the critical role of the Arg327 residue in stabilizing the channel closed state and explicate for the first time the structural and functional change of a Kv10.2 channel mutation associated with neurological disease. PMID: 24133262
5. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
6. Three-dimensional structure of human Kv10.2 ion channel studied by single particle electron microscopy and molecular modeling PMID: 22792721
7. molecular identification and characterisation PMID: 12135768
8. Methylation of KCNH5 was present in 80% of NSCLC tissues but only in 14% of noncancerous tissues. PMID: 18349282
9. data suggest that the 'Per-Ant-Sim' (PAS) and cyclic nucleotide binding (cNBD) domains at the N- and C-termini form interacting oligomers that have roles in channel function PMID: 19172261

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HGNC: 6254

OMIM: 605716

KEGG: hsa:27133

STRING: 9606.ENSP00000321427

UniGene: Hs.27043