KCNK10 Antibody

1. The M2-glycine hinge controls the macroscopic currents of TREK1 channels. PMID: 28676394
2. This study showed that KCNK10 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders. PMID: 26381449
3. The selectivity filter conformations of alternative translation initiation isoforms and wild type human TREK-2 are similar in the S4 site and pHo position. PMID: 26271386
4. Results suggest that the cytosolic C-terminal domain and the bottom of transmembrane segment M2 are required for the 2-aminoethoxydiphenyl borate activation on TREK-2 channels PMID: 25982558
5. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2. PMID: 26332952
6. Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation PMID: 25168769
7. PLD2, but not PLD1, directly binds to the C terminus of TREK1 and TREK2. PMID: 25197053
8. crystal structures of TREK-2 channel in 2 conformations and in complex with norfluoxetine, a state-dependent blocker of TREK channels; results provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli and possible off-target effects of Prozac PMID: 25766236
9. High TREK-2 expression is associated with epithelial ovarian cancer. PMID: 23479219
10. Tissue-specific mRNA splicing regulates alternative translation initiation (ATI) of human K(2P)10.1 K+ background channels via recombination of 5 nucleotide motifs. PMID: 21669980
11. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. PMID: 11897838
12. Predicts the role of TREK-2 in brain ischemia, memory and other tissues.[REVIEW] PMID: 17689202

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HGNC: 6273

OMIM: 605873

KEGG: hsa:54207

STRING: 9606.ENSP00000310568

UniGene: Hs.560255