KCNQ5 Antibody

1. Phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid, which directly activates KCNQ5 and KCNQ3 via W265. PMID: 29748663
2. Phosphorylation of S53 on the amino terminus of Kv7.5 is essential for protein kinase A-dependent enhancement of channel activity in response to beta adrenergic receptor activation in vascular and airway smooth muscle cells. PMID: 30061510
3. identified P2RX2, KCNQ5, ERBB3 and SOCS3 to be associated with the progression of age-related hearing impairment PMID: 29325454
4. Our data support the involvement of KCNQ5 gene polymorphisms in the genetic susceptibility to high myopia and further exploration of KCNQ5 as a risk factor for high myopia. PMID: 28884119
5. These findings provide the first evidence linking PKC activation to suppression of Kv7 currents, membrane depolarization, and Ca(2+) influx via L-type voltage-sensitive Ca(2+) channels as a mechanism for histamine-induced bronchoconstriction. PMID: 28283479
6. both loss-of-function and gain-of-function KCNQ5 mutations, associated with increased excitability and decreased repolarization reserve, lead to pathophysiology. PMID: 28669405
7. Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation. PMID: 26969140
8. rs9351963 in KCNQ5 is a possible predictive factor of incidence of diarrhea in cancer patients treated with irinotecan chemotherapy. PMID: 25127363
9. suggestive loci for periodontitis: KCNQ5 on chromosome 6q13 in a Japanese population. study should contribute to further understanding of genetic factors for enhanced susceptibility to periodontitis. PMID: 25672891
10. Kv7.1/Kv7.5 form heterotetrameric channels increasing the diversity of structures which fine-tune blood vessel reactivity. The lipid raft localization of Kv7.1/Kv7.5 heteromers provides efficient spatial and temporal regulation of smooth muscle function. PMID: 24855057
11. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels. PMID: 24297175
12. characterized the cell-type specific spatial organization of the kcnq5 gene locus mediated by CTCF in detail using chromosome conformation capture (3C) and 3C-derived techniques PMID: 22347474
13. The results of this study indicated that Kv7.5 contributes to the spatial regulation of KCNE3. PMID: 22190306
14. Data show that KCNQ1 mRNA expression was increased and KCNQ5 decreased in the preterm preeclamptic women. PMID: 21730298
15. While KCNE1 slows activation and suppresses inward rectification, KCNE3 drastically inhibits KCNQ5 currents. PMID: 19910673
16. Src associates with KCNQ2-5 subunits but phosphorylates only KCNQ3-5. PMID: 15304482
17. In conclusion, this work demonstrates that inactivation is a key regulatory mechanism of Kv7.4 and Kv7.5 channels. PMID: 17237198
18. among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers. PMID: 18786918

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HGNC: 6299

OMIM: 607357

KEGG: hsa:56479

STRING: 9606.ENSP00000345055

UniGene: Hs.445324