KHDRBS3 Antibody

Code CSB-PA012156GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
KHDRBS3
Alternative Names
Etle antibody; etoile antibody; KH domain containing RNA binding signal transduction associated 3 antibody; KH domain containing RNA binding signal transduction associated protein 3 antibody; KH domain-containing antibody; KHDR3_HUMAN antibody; Khdrbs3 antibody; RNA binding protein T Star antibody; RNA-binding antibody; RNA-binding protein T-Star antibody; SALP antibody; Sam68 like mammalian protein 2 antibody; Sam68 like phosphotyrosine protein antibody; Sam68 like phosphotyrosine protein T STAR antibody; Sam68-like mammalian protein 2 antibody; Sam68-like phosphotyrosine protein antibody; signal transduction-associated protein 3 antibody; SLM 2 antibody; SLM-2 antibody; SLM2 antibody; T STAR antibody; TSTAR antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human KHDRBS3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity. May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing. Can bind FABP9 mRNA. May play a role as a negative regulator of cell growth. Inhibits cell proliferation.; (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.
Gene References into Functions
  1. Down-regulating the KHDRBS3 gene can cause G0/G1 phase arrest and inhibit cell proliferation in CAOV-3 cells. PMID: 28871947
  2. Sam68 and T-STAR could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA. PMID: 26758068
  3. Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro. PMID: 23923007
  4. SerpinB5 interacts with KHDRBS3 and FBXO32, and KHDRBS3 can interact with FBXO32 mRNA. PMID: 21725612
  5. SLM-2-dependent VEGF splicing indicates the importance of mRNA splice site selection for glomerular filtration barrier function. PMID: 15901763
  6. The T-STAR gene may participate in regulation of telomerase activity in human colon cancer HCT-116 cells in a parallel fashion. PMID: 16810759
  7. data implicate hsa-miR-30b, hsa-miR-30d and KHDRBS3 as putative oncogenic target(s) of a novel recurrent medulloblastoma amplicon at 8q24.22-q24.23 PMID: 19584924

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Subcellular Location
Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
Protein Families
KHDRBS family
Tissue Specificity
Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.
Database Links

HGNC: 18117

OMIM: 610421

KEGG: hsa:10656

STRING: 9606.ENSP00000348108

UniGene: Hs.444558

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