KIAA0391 Antibody

Code CSB-PA012187GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
KIAA0391
Alternative Names
Kiaa0391 antibody; KIAA0391 gene antibody; Mitochondrial ribonuclease P protein 3 antibody; Mitochondrial RNase P protein 3 antibody; Mitochondrial RNase P subunit 3 antibody; MRPP3 antibody; MRRP3_HUMAN antibody; PRORP antibody; Proteinaceous RNase P antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human KIAA0391
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.
Gene References into Functions
  1. This study presents the crystal structure of human MRPP3, which features a remarkably distorted and hence non-productive active site that authors propose will switch to a fully productive state only upon association with MRPP1, MRPP2 and pre-tRNA substrate. PMID: 25953853
  2. using a genome-wide association study, found that posttranscriptional modification of functionally important sites in mitochondrial transfer RNAs (tRNAs) is under strong genetic control, largely driven by a missense mutation in MRPP3 PMID: 24763589
  3. Inhibition of mitochondrial RNase P by beta-amyloid is an unspecific effect and is not mediated by beta-amyloid interaction with SDR5C1. PMID: 23755257
  4. Haplotypes in KIAA0391 and PSMA6 genes is a genetic link for myocardial infarction and coronary artery disease. PMID: 19624571
Subcellular Location
Mitochondrion.
Protein Families
PPR family, P subfamily
Database Links

HGNC: 19958

OMIM: 609947

KEGG: hsa:9692

STRING: 9606.ENSP00000454657

UniGene: Hs.458487

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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