KIF13B Antibody, FITC conjugated

Code CSB-PA873625LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) KIF13B Polyclonal antibody
Uniprot No. Q9NQT8
Target Names KIF13B
Alternative Names GAKIN antibody; Guanylate kinase associated kinesin antibody; KI13B_HUMAN antibody; KIAA0639 antibody; KIF 13B antibody; KIF13B antibody; Kinesin 13B antibody; Kinesin family member 13B antibody; Kinesin like protein GAKIN antibody; Kinesin like protein KIF13B antibody; Kinesin-like protein GAKIN antibody; Kinesin-like protein KIF13B antibody; OTTHUMP00000225649 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Kinesin-like protein KIF13B protein (1531-1701AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.
Gene References into Functions
  1. Study provides evidence that KIF13B and NPHP4 are both required for establishment of a specialized caveolin-1 membrane microdomain at the ciliary transition zone, which is essential for Shh-induced accumulation of SMO in the primary cilium as well as for activation of GLI-mediated target gene expression. PMID: 28134340
  2. Findings show that the high-affinity binding of KIF13B to DLG guanylate kinase (GK) domain does not require phosphorylation of KIF13B and that DLG binds to an unphosphorylated and autonomously folded domain within its stalk region (MAGUK binding stalk [MBS] domain) with high specificity and affinity. PMID: 27642159
  3. lnc-KIF13B-1, a long non-coding RNA (rs6434720) is associated with corticobasal degeneration. PMID: 26077951
  4. KIF13B is an essential molecular motor required for the trafficking of VEGFR2 from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis. PMID: 25128562
  5. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. PMID: 21057110
  6. These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation. PMID: 20194617
  7. These results suggest that, in neurons, the GAKIN-PIP3BP complex transports PIP3 to the neurite ends and regulates neuronal polarity formation. PMID: 16864656
  8. Binding of the SH3-I3-GUK module of hDlg to GAKIN activates the microtubule-stimulated ATPase activity of GAKIN by approximately 10-fold. We propose: the cargo-mediated regulation of motor activity is a general paradigm for the activation of kinesins. PMID: 17696365

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Subcellular Location Cytoplasm, cytoskeleton, Cell projection, axon
Protein Families TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Tissue Specificity Ubiquitous.
Database Links

HGNC: 14405

OMIM: 607350

KEGG: hsa:23303

STRING: 9606.ENSP00000427900

UniGene: Hs.444767

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