KIF6 Antibody

1. The result suggests that KIF6 rs20455 polymorphism may not be associated with coronary heart disease susceptibility. (Meta-analysis) PMID: 29304815
2. his represents the first study implicating KIF6 variants with obesity in men, and point to the possible involvement of this genetic locus in the known gender-related differences in coronary artery disease. PMID: 29295555
3. The Trp719Arg polymorphism of the KIF6 gene is an important risk factor for developing myocardial infarction and that allele 719Arg may have a protective association to present coronary heart disease in all populations [review; meta-analysis] PMID: 28096762
4. The absence of Trp719Arg polymorphism association with coronary artery disease (CAD) and CAD in stratified myocardial infarction cases indicates that the polymorphism is not associated with an increased risk among CAD patients from the Eastern Province of Saudi Arabia PMID: 26997531
5. KIF6 polymorphism rs20455 had a significant association with Coronary Heart Disease; statin therapy was more effective in rs20455 carriers than non-carriers PMID: 26443250
6. KIF6 719Arg allele may increase the risk of T2DM and T2DM + CHD only in Han Chinese men by modulating lipid metabolism. PMID: 25629058
7. Our case-control study suggests that Trp719Arg of KIF6 gene is associated with coronary heart disease in female Han Chinese through a post hoc analysis. PMID: 23236363
8. KIF6 719Arg allele was not an independent risk factor for angiographic coronary artery disease(CAD)susceptibility in northern China Han populations; it was associated with a significantly higher TG level, which may indicate increased myocardial infarction risk in angiographic CAD patients PMID: 23001387
9. These data suggest that decreased availability of functional KLF6 contributes to clinical prostate cancer progression. PMID: 22819534
10. In a meta-analysis involving 144,931 participants, the KIF6 719Arg allele was not associated with the relative risk of cardiovascular disease PMID: 22216121
11. Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. PMID: 22192511
12. Carriers of the KIF6 719Arg allele were not at increased risk of CAD/non-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India. PMID: 21810021
13. In patients with type 2 diabetes mellitus on hemodialysis, KIF6 Trp719Arg genotypes were not associated with adverse cardiovascular outcomes during follow-up or with the efficacy of atorvastatin therapy. PMID: 21871624
14. Discovered influence of polymorphic marker Trp719Arg of KIF6 gene on individual response to therapy with 10 mg/day of atorvastatin. PMID: 21943003
15. A combination of KIF6 719Arg carrier status and C-reactive protein levels modestly improves the prediction of risk of myocardial infarction among white men. PMID: 21406102
16. Use of KIF6 genotyping to guide statin therapy is not warranted in this heart protection trial, since no impact is found on KIF6 genotype, vascular risk or statin response. PMID: 21458191
17. Carriers of the KIF6 719Arg allele were not at increased risk of non-fatal myocardial infarction. PMID: 20927332
18. three highly linked SNPs in the KIF6 region were identified that predict differential reduction of coronary events from statin therapy. PMID: 20886236
19. review of data supporting association between KIF6 polymorphism and coronary heart disease (CHD) and association between KIF6 polymorphism and event reduction by statin therapy; discuss putative biologic role of this kinesin in the cause of CHD [review] PMID: 20854963
20. the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins (Review) PMID: 20659029
21. Observational study and clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20886236
22. Observational study of gene-disease association. (HuGE Navigator) PMID: 20927332
23. Meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20933357
24. Elderly carriers of the KIF6 719Arg variant with prior vascular disease received significant benefit from pravastatin therapy. PMID: 20215968
25. Kinesin-like protein-6 tryptophan719arginine polymorphism is not associated with risk of clinical coronary artery disease in this large replication study. PMID: 20933357
26. a relationship between the presence of endothelial colony-forming cells and Arg/Arg genotype in KIF6 in patients with acute myocardial infarction. PMID: 20044086
27. Observational study of gene-disease association. (HuGE Navigator) PMID: 20679960
28. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
29. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20403483
30. pravastatin therapy significantly and substantially reduced primary end point events in carriers of the KIF6 719Arg allele but not in noncarriers. PMID: 20403483
31. Observational study of gene-disease association. (HuGE Navigator) PMID: 19752551
32. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20215968
33. In both the CARE and the WOSCOPS trials, carriers of the KIF6 719Arg allele had an increased risk of coronary events, and pravastatin treatment substantially reduced that risk. PMID: 18222353
34. Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS. PMID: 18222354
35. Carriers of 719Arg receive significantly greater benefit from intensive statin therapy than do noncarriers, a superior benefit that appears to be due to a mechanism distinct from lipid or CRP lowering. PMID: 18222355
36. The KIF6 719Arg variant has been associated with an increased risk of coronary disease and an increased response to statin therapy. PMID: 18510970
37. Observational study of gene-disease association. (HuGE Navigator) PMID: 19023099
38. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 18222353
39. Observational study of gene-disease association. (HuGE Navigator) PMID: 18222354
40. Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18222355
41. Observational study of gene-disease association. (HuGE Navigator) PMID: 17975119
42. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18073581

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HGNC: 21202

OMIM: 613919

KEGG: hsa:221458

STRING: 9606.ENSP00000287152

UniGene: Hs.588202